Magnetic resonance imaging-proton density fat fraction (MRI-PDFF) is an emerging
quantitative imaging biomarker that accurately measures the fat fraction of tissue by …

Objectives Image-based detection of intralesional fat in focal liver lesions has been
established in diagnostic guidelines as a feature indicative of hepatocellular carcinoma …

The spleen plays a key role in iron homeostasis. It is the largest filter of the blood and
performs iron reuptake from old or damaged erythrocytes. Despite this role, spleen iron …

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
affecting approximately 25% of the global population. There is a strong association between …

Background Quantification of pancreatic fat (PF) and intrahepatic lipids (IHL) is of increasing
interest in subjects at risk for metabolic diseases. There is limited data available on short …

The study evaluates four physically motivated constraints in the estimation of the proton
density fat fraction (PDFF). Least squares approaches were developed for constraining the …

Investigation of the effect on accuracy and precision of different parameter settings is
important for quantitative MRI. The purpose of this study was to investigate T1 bias and …

(1) Background: Open-source software tools are available to estimate proton density fat
fraction (PDFF).(2) Methods: We compared four algorithms: complex-based with graph cut …

Objectives To compare the quantitative measurement of splenic and pancreatic iron content
using a commercial 3D-Dixon sequence (qDixon) versus an established fat-saturated R2 …

Aging, and the pathogenesis of many common diseases, involves iron homeostasis. A key
role in iron homeostasis is played by the spleen, which is the largest filter of the blood and …