Cancer is a multifaceted and complex pathology characterized by uncontrolled cell
proliferation and decreased apoptosis. Most cancers are recognized by an inflammatory …

The biological functions of clusterin (CLU, also known as ApoJ, SGP2, TRPM-2, CLI) have
been puzzling the researchers since its first discovery in the early 80's. We know that CLU is …

Background Clusterin is a chaperone protein associated with treatment resistance and
upregulated by apoptotic stressors such as chemotherapy. Custirsen is a second-generation …

Prostate cancer (PCa) is one of the most common cancer types in men worldwide. Heat
shock proteins (HSPs) are molecular chaperones that are widely implicated in the …

The discovery and targeting of genes mediating androgen-independence may lead to the
development of novel therapies that delay progression of hormone refractory prostate …

Novel biomarkers are needed to complement prostate specific antigen (PSA) in prostate
cancer (PCa) diagnostic screening programs. Glycoproteins represent a hitherto largely …

The successful use of high-dose synthetic estrogens to treat postmenopausal metastatic
breast cancer is the first effective 'chemical therapy'proven in clinical trial to treat any cancer …

The lack of serum biomarkers for head and neck carcinoma limits early diagnosis,
monitoring of advanced disease, and prediction of relapses in patients. We conducted a …

Enhanced serum secreted clusterin (sCLU) protein was associated with progression, poor
prognosis and chemotherapy sensitivity evaluation in malignant patients. However, the …

Background Clusterin is a secreted glycoprotein that is upregulated in a variety of cell lines
in response to stress, and enhances cell survival. A second nuclear isoform of clusterin that …