Tumor microenvironment: Challenges and opportunities in targeting metastasis of triple negative breast cancer

KGK Deepak, R Vempati, GP Nagaraju… - Pharmacological …, 2020 - Elsevier
Triple negative breast cancer (TNBC) is most aggressive subtype of breast cancers with high
probability of metastasis as well as lack of specific targets and targeted therapeutics. TNBC …

Breast cancer: epidemiology and etiology

ZQ Tao, A Shi, C Lu, T Song, Z Zhang… - Cell biochemistry and …, 2015 - Springer
Breast cancer, the most frequently occurring cancer in women, is a major public health
problem, with 1,384,155 estimated new cases worldwide with nearly 459,000 related …

Pembrolizumab plus chemotherapy versus placebo plus chemotherapy for previously untreated locally recurrent inoperable or metastatic triple-negative breast cancer …

J Cortes, DW Cescon, HS Rugo, Z Nowecki, SA Im… - The Lancet, 2020 - thelancet.com
Background Pembrolizumab monotherapy showed durable antitumour activity and
manageable safety in patients with metastatic triple-negative breast cancer. We aimed to …

Effect of capecitabine maintenance therapy using lower dosage and higher frequency vs observation on disease-free survival among patients with early-stage triple …

X Wang, SS Wang, H Huang, L Cai, L Zhao, RJ Peng… - Jama, 2021 - jamanetwork.com
Importance Among all subtypes of breast cancer, triple-negative breast cancer has a
relatively high relapse rate and poor outcome after standard treatment. Effective strategies to …

[HTML][HTML] Recent therapeutic trends and promising targets in triple negative breast cancer

SY Hwang, S Park, Y Kwon - Pharmacology & therapeutics, 2019 - Elsevier
Breast cancer accounts for 25% of all types of cancer in women, and triple negative breast
cancer (TNBC) comprises around 15~ 20% of breast cancers. Conventional chemotherapy …

Phase II trial of bicalutamide in patients with androgen receptor–positive, estrogen receptor–negative metastatic breast cancer

A Gucalp, S Tolaney, SJ Isakoff, JN Ingle, MC Liu… - Clinical cancer …, 2013 - AACR
Purpose: Patients with hormone receptor–negative breast cancer generally do not benefit
from endocrine-targeted therapies. However, a subset with androgen receptor (AR) …

Triple-negative breast cancer

WD Foulkes, IE Smith… - New England journal of …, 2010 - Mass Medical Soc
Triple-negative breast cancer, so called because it lacks expression of the estrogen
receptor, progesterone receptor, and HER2, is often, but not always, a basal-like breast …

Biology and management of patients with triple-negative breast cancer

P Sharma - The oncologist, 2016 - academic.oup.com
Triple-negative breast cancer (TNBC) accounts for 15% of all breast cancers and is
associated with poor long-term outcomes compared with other breast cancer subtypes …

Taking ideas and discourse seriously: explaining change through discursive institutionalism as the fourth 'new institutionalism'

VA Schmidt - European political science review, 2010 - cambridge.org
All three of the traditionally recognized new institutionalisms–rational choice, historical, and
sociological–have increasingly sought to 'endogenize'change, which has often meant a turn …

Perspectives on triple-negative breast cancer: current treatment strategies, unmet needs, and potential targets for future therapies

GK Gupta, AL Collier, D Lee, RA Hoefer, V Zheleva… - Cancers, 2020 - mdpi.com
Triple-negative breast cancer (TNBC), characterized by the absence or low expression of
estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor …