Amorphous solid dispersions (ASDs) are among the most popular and widely studied
solubility enhancement techniques. Since their inception in the early 1960s, the formulation …

Does the performance of an amorphous solid dispersion rely on having 100% amorphous
content? What specifications are appropriate for crystalline content within an amorphous …

Hot melt extrusion (HME) has been widely used as a continuous and highly flexible
pharmaceutical manufacturing process for the production of a variety of dosage forms. In …

Solid-state NMR has been increasingly recognized as a high-resolution and versatile
spectroscopic tool to characterize drug substances and products. However, the analysis of …

To study the potential impacts of shear stress on cellulose nanocrystals (CNCs), a
microcapillary rheometer was employed to repeatedly shear approximately 10 mL of 6 wt …

Hot melt extrusion (HME) to prepare amorphous solid dispersions (ASDs) at temperatures
below the drug's melting point requires the crystalline drug to dissolve into the molten …

Asthma is a common chronic disease affecting the airways in the lungs. The receptors of
allergic cytokines, including interleukin (IL)-4, IL-5, and IL-13, trigger the Janus kinase …

Oral drug therapy requiring large quantities of active pharmaceutical ingredients (APIs) can
cause a substantial pill burden, which can increase nonadherence and worsen healthcare …

In today's world with increasing patient population, the demand for pharmaceutical
medications is increasing enormously. However, poor solubility of drug substances and …

In recent years, the demand for developing patient-centric dosage forms is increasing
enormously with the increasing patient population. Much research is ongoing exploring …