The function of the mammalian heart depends on the interplay between different cardiac cell
types. The deployment of these cells, with precise spatiotemporal regulation, is also …

The origins of the mesenchymal cells participating in tissue repair and pathological
processes, notably tissue fibrosis, tumor invasiveness, and metastasis, are poorly …

Long noncoding RNAs (lncRNAs) are often expressed in a development-specific manner,
yet little is known about their roles in lineage commitment. Here, we identified Braveheart …

Mouse heart development arises from Mesp1-expressing cardiovascular progenitors (CPs)
that are specified during gastrulation. The molecular processes that control early regional …

The epithelial to mesenchymal transition (EMT) plays crucial roles in the formation of the
body plan and in the differentiation of multiple tissues and organs. EMT also contributes to …

The events that convert adherent epithelial cells into individual migratory cells that can
invade the extracellular matrix are known collectively as epithelial-mesenchymal transition …

Genetic studies have identified the key signalling pathways and developmentally regulated
transcription factors that govern cell lineage allocation and axis patterning in the early …

Cardiac development arises from two sources of mesoderm progenitors, the first heart field
(FHF) and the second (SHF). Mesp1 has been proposed to mark the most primitive …

Understanding heart development on a molecular level is a prerequisite for uncovering the
causes of congenital heart diseases. Therapeutic approaches that try to enhance cardiac …

Heart disease is the leading cause of mortality and morbidity in the western world. The heart
has little regenerative capacity after damage, leading to much interest in understanding the …