Narcolepsy is a rare brain disorder that reflects a selective loss or dysfunction of orexin (also
known as hypocretin) neurons of the lateral hypothalamus. Narcolepsy type 1 (NT1) is …

Narcolepsy with cataplexy is a disabling sleep disorder affecting 0· 02% of adults worldwide.
It is characterised by severe, irresistible daytime sleepiness and sudden loss of muscle tone …

Much has been learned about the pathophysiology of narcolepsy over the last several
decades. It is likely that hypocretin-producing cells in the lateral hypothalamus are …

In the absence of a golden standard for the diagnosis of narcolepsy, the clinical spectrum of
disorder remains controversial. The aims of this study were (1) to determine frequency and …

Concentrations of CSF hypocretin-1 (formerly orexin A) have been measured in many
patients with sleep or neurological conditions. Low CSF hypocretin-1 is most predictive of …

Since their discovery in 1998, the hypocretins (orexins)—peptides that are produced by a
group of neurons situated in the posterolateral hypothalamus—have been shown to excite …

The complexity of sleep–wake regulation, in addition to the many environmental influences,
includes genetic predisposing factors, which begin to be discovered. Most of the current …

Narcolepsy is a term that was initially coined by Gélineáu in 1880 and is a chronic
neurological sleep disorder that manifests as a difficulty in maintaining wakefulness and …

Abstract Study Objectives: The impairment of hypocretin neurotransmission system is
considered to play a major role in the pathophysiology of narcolepsy. It has been …

Narcolepsy is a neurologic illness that typically begins in the second and third decades of
life. It is chronic in nature and negatively impacts the quality of life of affected patients. The …