Anti-angiogenic agents—overcoming tumour endothelial cell anergy and improving immunotherapy outcomes

ZR Huinen, EJM Huijbers, JR van Beijnum… - Nature Reviews …, 2021 - nature.com
Immune checkpoint inhibitors have revolutionized medical oncology, although currently only
a subset of patients has a response to such treatment. A compelling body of evidence …

[HTML][HTML] Imbalances in circulating angiogenic factors in the pathophysiology of preeclampsia and related disorders

S Rana, SD Burke, SA Karumanchi - American journal of obstetrics and …, 2022 - Elsevier
Preeclampsia is a devastating medical complication of pregnancy that can lead to significant
maternal and fetal morbidity and mortality. It is currently believed that there is abnormal …

The placenta in fetal growth restriction: what is going wrong?

C Sun, KM Groom, C Oyston, LW Chamley, AR Clark… - Placenta, 2020 - Elsevier
The placenta is essential for the efficient delivery of nutrients and oxygen from mother to
fetus to maintain normal fetal growth. Dysfunctional placental development underpins many …

[HTML][HTML] Placental adaptations in growth restriction

S Zhang, TRH Regnault, PL Barker, KJ Botting… - Nutrients, 2015 - mdpi.com
The placenta is the primary interface between the fetus and mother and plays an important
role in maintaining fetal development and growth by facilitating the transfer of substrates and …

[HTML][HTML] Regulation of vascular growth and function in the human placenta

GJ Burton, DS Charnock-Jones, E Jauniaux - Reproduction, 2009 - rep.bioscientifica.com
During the course of 9 months, the human placenta develops into a highly vascular organ.
Vasculogenesis starts during the third week post-conception. Hemangioblastic cell cords …

[HTML][HTML] MicroRNAs: crucial regulators of placental development

H Hayder, J O'Brien, U Nadeem, C Peng - Reproduction, 2018 - rep.bioscientifica.com
MicroRNAs (miRNAs) are small non-coding single-stranded RNAs that are integral to a wide
range of cellular processes mainly through the regulation of translation and mRNA stability …

Vascular biology of the placenta

H Weiler - Endothelial Cells in Health and Disease, 2005 - taylorfrancis.com
The placenta is a gender-specific transitory organ with the sole purpose of enabling the
growth and development of the fetus. It mediates the efficient transfer and exchange of …

Placental formation in early pregnancy: how is the centre of the placenta made?

AL Boss, LW Chamley, JL James - Human reproduction update, 2018 - academic.oup.com
BACKGROUND Correct development of the placenta is critical to establishing pregnancy
and inadequate placentation leads to implantation failure and miscarriage, as well as later …

[HTML][HTML] The impact of infection in pregnancy on placental vascular development and adverse birth outcomes

AM Weckman, M Ngai, J Wright, CR McDonald… - Frontiers in …, 2019 - frontiersin.org
Healthy fetal development is dependent on nutrient and oxygen transfer via the placenta.
Optimal growth and function of placental vasculature is therefore essential to support in …

[HTML][HTML] Perinatal derivatives: where do we stand? A roadmap of the human placenta and consensus for tissue and cell nomenclature

AR Silini, R Di Pietro, I Lang-Olip, F Alviano… - … in bioengineering and …, 2020 - frontiersin.org
Progress in the understanding of the biology of perinatal tissues has contributed to the
breakthrough revelation of the therapeutic effects of perinatal derivatives (PnD), namely birth …