Mitochondria, the main provider of energy in eukaryotic cells, contains more than 1000
different proteins and is closely related to the development of cells. However, damaged …

ClpP is a highly conserved serine protease that is a critical enzyme in maintaining protein
homeostasis and is an important drug target in pathogenic bacteria and various cancers. In …

Hsp70 interactions are critical for cellular viability and the response to stress. Previous
attempts to characterize Hsp70 interactions have been limited by their transient nature and …

All known organisms encode 20 canonical amino acids by base triplets in the genetic code.
The cellular translational machinery produces proteins consisting mainly of these amino …

The mitochondrial matrix peptidase CLPP is crucial during cell stress. Its loss causes
Perrault syndrome type 3 (PRLTS3) with infertility, neurodegeneration, and a growth deficit …

Lon proteases, members of the AAA+ superfamily of enzymes, are key components of the
protein quality control system in bacterial cells, as well as in the mitochondria and other …

As more protein structure models have been determined from cryogenic electron microscopy
(cryo-EM) density maps, establishing how to evaluate the model accuracy and how to …

ClpAP, a two-ring AAA+ protease, degrades N-end-rule proteins bound by the ClpS adaptor.
Here we present high-resolution cryo-EM structures of Escherichia coli ClpAPS complexes …

The Lon protease is the prototype of a family of proteolytic machines with adenosine
triphosphatase modules built into a substrate degradation chamber. Lon is known to …

The double-ring AAA+ ATPase Pex1/Pex6 is required for peroxisomal receptor recycling
and is essential for peroxisome formation. Pex1/Pex6 mutations cause severe peroxisome …