Osteoarthritis is thought to be the most prevalent chronic joint disease. The incidence of
osteoarthritis is rising because of the ageing population and the epidemic of obesity. Pain …

Objective This study was design to examine the diagnostic performance of cartilage
oligomeric matrix protein (COMP), C-terminal cross-linking telopeptide of type II collagen …

Background Treatment of severe osteoarthritis (OA) in relatively young patients is
challenging. Although successful, total knee prosthesis has a limited lifespan, with the risk of …

Background Modification of joint tissue damage is challenging in late-stage osteoarthritis
(OA). Few options are available for treating end-stage knee OA other than joint replacement …

In this Review we describe three approaches for cartilage tissue repair at the rheumatology–
orthopaedics interface: disease-modifying osteoarthritis (OA) drug (DMOAD) treatment; cell …

Purpose Both, knee joint distraction as a relatively new approach and valgus-producing
opening-wedge high tibial osteotomy (HTO), are knee-preserving treatments for knee …

Objective In end-stage knee osteoarthritis, total knee arthroplasty (TKA) may finally become
inevitable. At a relatively young age, this comes with the risk of future revision surgery …

Purpose The Applied Public-Private Research enabling OsteoArthritis Clinical Headway
(APPROACH) consortium intends to prospectively describe in detail, preselected patients …

Background: Meniscal allograft transplantation (MAT) is a widely performed surgical
technique used to reconstruct meniscal deficiencies after meniscectomy. However, the long …

Objective Both, knee joint distraction (KJD) and high tibial osteotomy (HTO) are joint-
preserving surgeries that postpone total knee arthroplasty (TKA) in younger osteoarthritis …