Current and emerging strategies for management of myelodysplastic syndromes
C Saygin, HE Carraway - Blood reviews, 2021 - Elsevier
Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis with
varying degrees of dysplasia and peripheral cytopenias. MDS are driven by structural …
varying degrees of dysplasia and peripheral cytopenias. MDS are driven by structural …
Current landscape of translational and clinical research in myelodysplastic syndromes/neoplasms (MDS): Proceedings from the 1st International Workshop on MDS …
JP Bewersdorf, Z Xie, R Bejar, U Borate, J Boultwood… - Blood Reviews, 2023 - Elsevier
Biological events that contribute to the pathogenesis of myelodysplastic
syndromes/neoplasms (MDS) are becoming increasingly characterized and are being …
syndromes/neoplasms (MDS) are becoming increasingly characterized and are being …
Relationship between clone metrics and clinical outcome in clonal cytopenia
Clonal cytopenia of undetermined significance (CCUS) is associated with an increased risk
of developing a myeloid neoplasm with myelodysplasia (MN). To identify the features of the …
of developing a myeloid neoplasm with myelodysplasia (MN). To identify the features of the …
Clinical and molecular determinants of clonal evolution in aplastic anemia and paroxysmal nocturnal hemoglobinuria
PURPOSE Secondary myeloid neoplasms (sMNs) remain the most serious long-term
complications in patients with aplastic anemia (AA) and paroxysmal nocturnal …
complications in patients with aplastic anemia (AA) and paroxysmal nocturnal …
Clonal architecture predicts clinical outcomes and drug sensitivity in acute myeloid leukemia
The impact of clonal heterogeneity on disease behavior or drug response in acute myeloid
leukemia remains poorly understood. Using a cohort of 2,829 patients, we identify features …
leukemia remains poorly understood. Using a cohort of 2,829 patients, we identify features …
Machine learning demonstrates that somatic mutations imprint invariant morphologic features in myelodysplastic syndromes
Morphologic interpretation is the standard in diagnosing myelodysplastic syndrome (MDS),
but it has limitations, such as varying reliability in pathologic evaluation and lack of …
but it has limitations, such as varying reliability in pathologic evaluation and lack of …
Machine learning integrates genomic signatures for subclassification beyond primary and secondary acute myeloid leukemia
Although genomic alterations drive the pathogenesis of acute myeloid leukemia (AML),
traditional classifications are largely based on morphology, and prototypic genetic founder …
traditional classifications are largely based on morphology, and prototypic genetic founder …
Leukemia relapse via genetic immune escape after allogeneic hematopoietic cell transplantation
S Pagliuca, C Gurnari, C Hercus, S Hergalant… - Nature …, 2023 - nature.com
Abstract Graft-versus-leukemia (GvL) reactions are responsible for the effectiveness of
allogeneic hematopoietic cell transplantation as a treatment modality for myeloid neoplasia …
allogeneic hematopoietic cell transplantation as a treatment modality for myeloid neoplasia …
Validation of the Molecular International Prognostic Scoring System in patients with myelodysplastic syndromes
Myelodysplastic syndrome (MDS) represents a heterogeneous group of disorders
encompassing a wide range of pathologically distinct subtypes associated with different …
encompassing a wide range of pathologically distinct subtypes associated with different …
Clonal evolution and hierarchy in myeloid malignancies
K Takahashi, T Tanaka - Trends in Cancer, 2023 - cell.com
Myeloid malignancies, a group of hematopoietic disorders that includes acute myeloid
leukemia (AML), myelodysplastic syndromes (MDS), and myeloproliferative neoplasms …
leukemia (AML), myelodysplastic syndromes (MDS), and myeloproliferative neoplasms …