Monoallelic gene expression is a remarkable process in which transcription occurs from only
one of two homologous alleles in a diploid cell. Interestingly, between 0.5% and 15% of …

Congenital hypothyroidism (CH) is a neonatal endocrine disorder that might occur as itself
or be associated to congenital extra‐thyroidal defects. About 85% of affected subjects …

Despite the well-established role of nuclear organization in the regulation of gene
expression, little is known about the reverse: how transcription shapes the spatial …

An unexpectedly large number of human autosomal genes are subject to monoallelic
expression (MAE). Our analysis of 4,227 such genes uncovers surprisingly high genetic …

ASARs are long noncoding RNA genes that control replication timing of entire human
chromosomes in cis. The three known ASAR genes are located on human chromosomes 6 …

Some imprinted genes exhibit parental origin specific expression bias rather than being
transcribed exclusively from one copy. The physiological relevance of this remains poorly …

Abstract The 2016 Database Issue of Nucleic Acids Research starts with overviews of the
resources provided by three major bioinformatics centers, the US National Center for …

In mammals, several classes of monoallelic genes have been identified, including those
subject to X-chromosome inactivation (XCI), genomic imprinting, and random monoallelic …

To date, the molecular mechanisms that underline aggressiveness and resistance to
tyrosine kinase inhibitors in some thyroid carcinomas (TCs) are not known yet. We report the …

Imprinting is a classic mammalian epigenetic phenomenon that results in expression from a
single parental allele. Imprinting defects can lead to inappropriate expression from the …