Random monoallelic expression: regulating gene expression one allele at a time
MA Eckersley-Maslin, DL Spector - Trends in Genetics, 2014 - cell.com
Monoallelic gene expression is a remarkable process in which transcription occurs from only
one of two homologous alleles in a diploid cell. Interestingly, between 0.5% and 15% of …
one of two homologous alleles in a diploid cell. Interestingly, between 0.5% and 15% of …
Molecular defects in thyroid dysgenesis
Congenital hypothyroidism (CH) is a neonatal endocrine disorder that might occur as itself
or be associated to congenital extra‐thyroidal defects. About 85% of affected subjects …
or be associated to congenital extra‐thyroidal defects. About 85% of affected subjects …
Spatial organization of transcribed eukaryotic genes
S Leidescher, J Ribisel, S Ullrich, Y Feodorova… - Nature cell …, 2022 - nature.com
Despite the well-established role of nuclear organization in the regulation of gene
expression, little is known about the reverse: how transcription shapes the spatial …
expression, little is known about the reverse: how transcription shapes the spatial …
Genes with monoallelic expression contribute disproportionately to genetic diversity in humans
An unexpectedly large number of human autosomal genes are subject to monoallelic
expression (MAE). Our analysis of 4,227 such genes uncovers surprisingly high genetic …
expression (MAE). Our analysis of 4,227 such genes uncovers surprisingly high genetic …
[HTML][HTML] Epigenetic control of chromosome-associated lncRNA genes essential for replication and stability
MB Heskett, AE Vouzas, LG Smith, PA Yates… - Nature …, 2022 - nature.com
ASARs are long noncoding RNA genes that control replication timing of entire human
chromosomes in cis. The three known ASAR genes are located on human chromosomes 6 …
chromosomes in cis. The three known ASAR genes are located on human chromosomes 6 …
[HTML][HTML] Trappc9 deficiency causes parent-of-origin dependent microcephaly and obesity
Some imprinted genes exhibit parental origin specific expression bias rather than being
transcribed exclusively from one copy. The physiological relevance of this remains poorly …
transcribed exclusively from one copy. The physiological relevance of this remains poorly …
The 2016 database issue of Nucleic Acids Research and an updated molecular biology database collection
DJ Rigden, XM Fernández-Suárez… - Nucleic acids …, 2016 - academic.oup.com
Abstract The 2016 Database Issue of Nucleic Acids Research starts with overviews of the
resources provided by three major bioinformatics centers, the US National Center for …
resources provided by three major bioinformatics centers, the US National Center for …
Allelic imbalance is a prevalent and tissue-specific feature of the mouse transcriptome
In mammals, several classes of monoallelic genes have been identified, including those
subject to X-chromosome inactivation (XCI), genomic imprinting, and random monoallelic …
subject to X-chromosome inactivation (XCI), genomic imprinting, and random monoallelic …
[HTML][HTML] Thyroid cancer harboring PTEN and TP53 mutations: A peculiar molecular and clinical case report
C Colombo, G Pogliaghi, D Tosi, M Muzza… - Frontiers in …, 2022 - frontiersin.org
To date, the molecular mechanisms that underline aggressiveness and resistance to
tyrosine kinase inhibitors in some thyroid carcinomas (TCs) are not known yet. We report the …
tyrosine kinase inhibitors in some thyroid carcinomas (TCs) are not known yet. We report the …
Visualizing allele-specific expression in single cells reveals epigenetic mosaicism in an H19 loss-of-imprinting mutant
Imprinting is a classic mammalian epigenetic phenomenon that results in expression from a
single parental allele. Imprinting defects can lead to inappropriate expression from the …
single parental allele. Imprinting defects can lead to inappropriate expression from the …