Brain development in humans is achieved through precise spatiotemporal genetic control,
the mechanisms of which remain largely elusive. Recently, integration of technological …

Semaphorins are extracellular signaling proteins that are essential for the development and
maintenance of many organs and tissues. The more than 20-member semaphorin protein …

Major depressive disorder (MDD) is the leading cause of disability worldwide. There is an
urgent need for objective biomarkers to diagnose this highly heterogeneous syndrome …

Importance Large-scale neuroimaging studies have revealed group differences in cortical
thickness across many psychiatric disorders. The underlying neurobiology behind these …

Background Temporal lobe epilepsy is a common and frequently intractable seizure
disorder. Its pathogenesis is thought to involve large-scale alterations to the expression of …

Mesocorticolimbic dopamine circuity undergoes a protracted maturation during adolescent
life. Stable adult levels of behavioral functioning in reward, motivational, and cognitive …

Astrocytes, which are homeostatic cells of the central nervous system (CNS), display
remarkable heterogeneity in their morphology and function. Besides their physical and …

Intellectual disability and autism spectrum disorder (ASD) are common, and genetic testing
is increasingly performed in individuals with these diagnoses to inform prognosis, refine …

Decline in biological resilience (ability to recover) is a key manifestation of aging that
contributes to increase in vulnerability to death with age eventually limiting longevity even in …

Spinal cord injury (SCI) results in massive neuronal death, axonal disruption, and cascading
inflammatory response, which causes further damage to impaired neurons. The survived …