Mitochondrial adaptation in nonalcoholic fatty liver disease: novel mechanisms and treatment strategies
Nonalcoholic fatty liver disease (NAFLD) is prevalent in patients with obesity or type 2
diabetes. Nonalcoholic steatohepatitis (NASH), encompassing steatosis with inflammation …
diabetes. Nonalcoholic steatohepatitis (NASH), encompassing steatosis with inflammation …
Astaxanthin as a novel mitochondrial regulator: a new aspect of carotenoids, beyond antioxidants
Y Nishida, A Nawaz, K Hecht, K Tobe - Nutrients, 2021 - mdpi.com
Astaxanthin is a member of the carotenoid family that is found abundantly in marine
organisms, and has been gaining attention in recent years due to its varied biological …
organisms, and has been gaining attention in recent years due to its varied biological …
mitoNEET as a novel drug target for mitochondrial dysfunction
Highlights•Mitochondrial dysfunction plays an important part in several diseases.•mitoNEET
is a mitochondrial protein that regulates bioenergetics in cells.•mitoNEET ligands to date are …
is a mitochondrial protein that regulates bioenergetics in cells.•mitoNEET ligands to date are …
Palmitoleic Acid (N‐7) Attenuates the Immunometabolic Disturbances Caused by a High‐Fat Diet Independently of PPARα
Palmitoleic acid (PMA) has anti‐inflammatory and antidiabetic activities. Here we tested
whether these effects of PMA on glucose homeostasis and liver inflammation, in mice fed …
whether these effects of PMA on glucose homeostasis and liver inflammation, in mice fed …
Pioglitazone leads to an inactivation and disassembly of complex I of the mitochondrial respiratory chain
I García-Ruiz, P Solís-Muñoz, D Fernández-Moreira… - BMC biology, 2013 - Springer
Background Thiazolidinediones are antidiabetic agents that increase insulin sensitivity but
reduce glucose oxidation, state 3 respiration, and activity of complex I of the mitochondrial …
reduce glucose oxidation, state 3 respiration, and activity of complex I of the mitochondrial …
Rosiglitazone ameliorates cardiac and skeletal muscle dysfunction by correction of energetics in huntington's disease
M Tomczyk, A Braczko, P Mierzejewska, M Podlacha… - Cells, 2022 - mdpi.com
Huntington's disease (HD) is a rare neurodegenerative disease that is accompanied by
skeletal muscle atrophy and cardiomyopathy. Tissues affected by HD (central nervous …
skeletal muscle atrophy and cardiomyopathy. Tissues affected by HD (central nervous …
[HTML][HTML] Mitochondrial dysfunction has divergent, cell type-dependent effects on insulin action
SD Martin, S Morrison, N Konstantopoulos… - Molecular metabolism, 2014 - Elsevier
The contribution of mitochondrial dysfunction to insulin resistance is a contentious issue in
metabolic research. Recent evidence implicates mitochondrial dysfunction as contributing to …
metabolic research. Recent evidence implicates mitochondrial dysfunction as contributing to …
Discovery of novel insulin sensitizers: promising approaches and targets
Insulin resistance is the undisputed root cause of type 2 diabetes mellitus (T2DM). There is
currently an unmet demand for safe and effective insulin sensitizers, owing to the restricted …
currently an unmet demand for safe and effective insulin sensitizers, owing to the restricted …
Pioglitazone inhibits mitochondrial pyruvate metabolism and glucose production in hepatocytes
CE Shannon, G Daniele, C Galindo… - The FEBS …, 2017 - Wiley Online Library
Pioglitazone is used globally for the treatment of type 2 diabetes mellitus (T2DM) and is one
of the most effective therapies for improving glucose homeostasis and insulin resistance in …
of the most effective therapies for improving glucose homeostasis and insulin resistance in …
Unraveling biochemical pathways affected by mitochondrial dysfunctions using metabolomic approaches
Mitochondrial dysfunction (s)(MDs) can be defined as alterations in the mitochondria,
including mitochondrial uncoupling, mitochondrial depolarization, inhibition of the …
including mitochondrial uncoupling, mitochondrial depolarization, inhibition of the …