Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics

SA Polyzos, J Kountouras, CS Mantzoros - Metabolism, 2019 - Elsevier
The obesity epidemic is closely associated with the rising prevalence and severity of
nonalcoholic fatty liver disease (NAFLD): obesity has been linked not only with simple …

Nonalcoholic steatohepatitis: the role of peroxisome proliferator-activated receptors

S Francque, G Szabo, MF Abdelmalek… - Nature reviews …, 2021 - nature.com
The increasing epidemic of obesity worldwide is linked to serious health effects, including
increased prevalence of type 2 diabetes mellitus, cardiovascular disease and nonalcoholic …

Immunological mechanisms and therapeutic targets of fatty liver diseases

H Wang, W Mehal, LE Nagy, Y Rotman - Cellular & Molecular …, 2021 - nature.com
Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are the two major
types of chronic liver disease worldwide. Inflammatory processes play key roles in the …

Recent advances in alcohol-related liver disease (ALD): summary of a Gut round table meeting

MA Avila, JF Dufour, AL Gerbes, F Zoulim, R Bataller… - Gut, 2020 - gut.bmj.com
Alcohol-related liver disease (ALD), which includes a range of disorders of different severity
and is one of the most prevalent types of liver disease worldwide, has recently regained …

Inflammatory pathways in alcoholic steatohepatitis

B Gao, MF Ahmad, LE Nagy, H Tsukamoto - Journal of hepatology, 2019 - Elsevier
Inflammatory processes are primary contributors to the development and progression of
alcoholic steatohepatitis (ASH), with severe alcoholic hepatitis characterised by non …

Multiscale biomechanics and mechanotransduction from liver fibrosis to cancer

N Li, X Zhang, J Zhou, W Li, X Shu, Y Wu… - Advanced Drug Delivery …, 2022 - Elsevier
A growing body of multiscale biomechanical studies has been proposed to highlight the
mechanical cues in the development of hepatic fibrosis and cancer. At the cellular level …

Tumor-associated neutrophils in hepatocellular carcinoma pathogenesis, prognosis, and therapy

K Arvanitakis, I Mitroulis, G Germanidis - Cancers, 2021 - mdpi.com
Simple Summary Hepatocellular carcinoma is the most prevalent primary liver cancer,
accounting for> 80% of primary liver cancers worldwide. Inflammation has come to light as a …

[HTML][HTML] Hepatic stellate cell-immune interactions in NASH

JK Carter, SL Friedman - Frontiers in Endocrinology, 2022 - frontiersin.org
Nonalcoholic fatty liver disease (NAFLD) is the dominant cause of liver disease worldwide.
Nonalcoholic steatohepatitis (NASH), a more aggressive presentation of NAFLD, is …

[PDF][PDF] MicroRNA‐223 ameliorates nonalcoholic steatohepatitis and cancer by targeting multiple inflammatory and oncogenic genes in hepatocytes

Y He, S Hwang, Y Cai, SJ Kim, M Xu, D Yang… - …, 2019 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) represents a spectrum of diseases ranging from
simple steatosis to more severe forms of liver injury including nonalcoholic steatohepatitis …

[HTML][HTML] The role of innate immune cells in nonalcoholic fatty liver disease

M Nati, KJ Chung, T Chavakis - Journal of innate immunity, 2022 - karger.com
Nonalcoholic fatty liver disease (NAFLD) is a very common hepatic pathology featuring
steatosis and is linked to obesity and related conditions, such as the metabolic syndrome …