[HTML][HTML] Exercise training maintains cardiovascular health: signaling pathways involved and potential therapeutics
Exercise training has been widely recognized as a healthy lifestyle as well as an effective
non-drug therapeutic strategy for cardiovascular diseases (CVD). Functional and …
non-drug therapeutic strategy for cardiovascular diseases (CVD). Functional and …
The critical role of Akt in cardiovascular function
P Abeyrathna, Y Su - Vascular pharmacology, 2015 - Elsevier
Akt kinase, a member of AGC kinases, is important in many cellular functions including
proliferation, migration, cell growth and metabolism. There are three known Akt isoforms …
proliferation, migration, cell growth and metabolism. There are three known Akt isoforms …
Molecular basis of physiological heart growth: fundamental concepts and new players
The heart hypertrophies in response to developmental signals as well as increased
workload. Although adult-onset hypertrophy can ultimately lead to disease, cardiac …
workload. Although adult-onset hypertrophy can ultimately lead to disease, cardiac …
Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies
Cardiac hypertrophy can be defined as an increase in heart mass. Pathological cardiac
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …
Physiological and pathological cardiac hypertrophy
I Shimizu, T Minamino - Journal of molecular and cellular cardiology, 2016 - Elsevier
The heart must continuously pump blood to supply the body with oxygen and nutrients. To
maintain the high energy consumption required by this role, the heart is equipped with …
maintain the high energy consumption required by this role, the heart is equipped with …
Molecular pathways underlying cardiac remodeling during pathophysiological stimulation
I Kehat, JD Molkentin - Circulation, 2010 - Am Heart Assoc
Cardiac remodeling involves molecular, cellular, and in-terstitial changes that manifest
clinically as changes in size, shape, and function of the heart after injury or stress …
clinically as changes in size, shape, and function of the heart after injury or stress …
Regulation of cardiac hypertrophy by intracellular signalling pathways
J Heineke, JD Molkentin - Nature reviews Molecular cell biology, 2006 - nature.com
The mammalian heart is a dynamic organ that can grow and change to accommodate
alterations in its workload. During development and in response to physiological stimuli or …
alterations in its workload. During development and in response to physiological stimuli or …
MicroRNA-133 controls cardiac hypertrophy
Growing evidence indicates that microRNAs (miRNAs or miRs) are involved in basic cell
functions and oncogenesis. Here we report that miR-133 has a critical role in determining …
functions and oncogenesis. Here we report that miR-133 has a critical role in determining …
Hypertrophy of the heart: a new therapeutic target?
Recent studies call into question the necessity of hypertrophic growth of the heart as a
“compensatory” response to hemodynamic stress. These findings, coupled with recent …
“compensatory” response to hemodynamic stress. These findings, coupled with recent …
Sirtuins: guardians of mammalian healthspan
W Giblin, ME Skinner, DB Lombard - Trends in Genetics, 2014 - cell.com
The first link between sirtuins and longevity was made 15 years ago in yeast. These initial
studies sparked efforts by many laboratories working in diverse model organisms to …
studies sparked efforts by many laboratories working in diverse model organisms to …