The opportunistic human pathogen Pseudomonas aeruginosa can cause severe infections
in immunocompromized people or cystic fibrosis (CF) patients. Because of its remarkable …

The cyclic GMP-AMP (cGAMP) synthase (cGAS) recognizes cytosolic DNA and synthesizes
the second messenger, cGAMP, thus activating the adaptor protein stimulator of interferon …

Cyclic dimeric guanosine monophosphate (c-di-GMP) serves as a second messenger that
modulates bacterial cellular processes, including biofilm formation. While proteins …

In bacteria, the monopolar localization of enzymes and protein complexes can result in a
bimodal distribution of enzyme activity between the dividing cells and heterogeneity of …

Pseudomonas aeruginosa is a Gram-negative bacterium that is able to survive and adapt in
a multitude of niches as well as thrive within many different hosts. This versatility lies within …

Pseudomonas aeruginosa grows as a biofilm under many environmental conditions, and the
bacterium can disperse from biofilms via highly regulated, dynamic processes. However …

Bifunctional enzymes, which contain two domains with opposing enzymatic activities, are
widely distributed in bacteria, but the regulatory mechanism (s) that prevent futile cycling are …

Root colonization by beneficial rhizobacteria determines their plant beneficial effects. The
messenger c-di-GMP is involved in the bacterial transition process between motility and …

Bacterial second messenger c‐di‐GMP upregulation is associated with the transition from
planktonic to sessile microbial lifestyle, inhibiting cellular motility, and virulence. However, in …

The incidence of melioidosis cases caused by the gram-negative pathogen Burkholderia
pseudomallei (BP) is seeing an increasing trend that has spread beyond its previously …