Colorectal cancer (CRC) is one of the most common aggressive carcinoma types worldwide,
characterized by unfavorable curative effect and poor prognosis. Epidemiological data re …

Insulin-like growth factors (IGFs) are peptides which exert mitogenic, endocrine and cytokine
activities. Together with their receptors, binding proteins and associated molecules, they …

Chronic kidney disease (CKD) has been defined by the presence of kidney damage with or
without reduced kidney function. It is often coexisting with other conditions such as …

Given the role of insulin resistance in colorectal cancer (CRC), we explored whether genetic
variants in insulin (INS), insulin receptor (INSR), insulin receptor substrate 1 (IRS1), insulin …

As a pathological condition, epilepsy is caused by abnormal neuronal discharge in brain
which will temporarily disrupt the cerebral functions. Epilepsy is a chronic disease which …

Background: Alterations in gene expression levels or mutations of tyrosine kinases are
detected in some human cancers. In this study, we examined whether serine threonine …

Insulin-like growth factors (IGFs) have been associated with growth, body size, physical
activity and colorectal cancer (CRC). We hypothesized that variants in IGF-related genes …

Background: Colorectal carcinoma (CRC) and non-alcoholic fatty liver disease (NAFLD)
share common risk factors. Insulin resistance (IR) has an important role in both diseases. It …

Early detection of colorectal cancer (CRC) increases the 5-year survival rate by 90%;
therefore, non-invasive biomarkers such as measurable circulating proteins for early …

Methods: Articles regarding the relationship between IGF1 rs5742714, rs6214, and rs6220
polymorphisms and cancer risk were selected by searching the PubMed, Embase, and Web …