Biological potential of carbazole derivatives

A Głuszyńska - European journal of medicinal chemistry, 2015 - Elsevier
Carbazole skeleton is the key structural motif of many biologically active compounds
including synthetic and natural products. Over the past several years, a large number of …

[HTML][HTML] Recent Developments and Biological Activities of N-Substituted Carbazole Derivatives: A Review

M Bashir, A Bano, AS Ijaz, BA Chaudhary - Molecules, 2015 - mdpi.com
Carbazoles represent an important class of heterocycles. These have been reported to
exhibit diverse biological activities such as antimicrobial, antitumor, antiepileptic …

Recent advancement in the discovery and development of COX-2 inhibitors: Insight into biological activities and SAR studies (2008–2019)

V Sharma, P Bhatia, O Alam, MJ Naim, F Nawaz… - Bioorganic …, 2019 - Elsevier
Cyclooxygenase-2 is a very important physiological enzyme playing key roles in various
biological functions especially in the mechanism of pain and inflammation, among other …

[HTML][HTML] Schiff's bases of quinazolinone derivatives: Synthesis and SAR studies of a novel series of potential anti-inflammatory and antioxidants

KP Rakesh, HM Manukumar, DC Gowda - Bioorganic & medicinal …, 2015 - Elsevier
A series of quinazolinone derived Schiff base derivatives 7–28 were synthesized and
characterized as novel antioxidants and anti-inflammatory agents. The in vitro antioxidant …

Current progress on antioxidants incorporating the pyrazole core

VLM Silva, J Elguero, AMS Silva - European journal of medicinal chemistry, 2018 - Elsevier
The search of new antioxidants, as drugs candidates, is an active field of medicinal
chemistry. The synthesis of compounds with antioxidant potential has increased in recent …

Eco-friendly synthesis, characterization, in-silico ADMET and molecular docking analysis of novel carbazole derivatives as antibacterial and antifungal agents

O Merzouki, N Arrousse, A El Barnossi… - Journal of Molecular …, 2023 - Elsevier
In search of novel biologically potent compounds, three novel organic molecules have been
synthesized. The structures of the prepared compounds have been characterized by …

[HTML][HTML] Design, synthesis, X-ray crystal structures, anticancer, DNA binding, and molecular modelling studies of pyrazole–pyrazoline hybrid derivatives

M Rana, H Hungyo, P Parashar, S Ahmad… - RSC …, 2023 - pubs.rsc.org
We have designed and synthesized three pyrazole analogs (4, 5a, 5b), pyrazole-based
chalcones (6a–6d) and (8a–8h), and N-formyl/acetyl 1, 3, 5-trisubstituted pyrazoline analogs …

LNL-Carbazole Pincer Ligand: More than the Sum of Its Parts

G Kleinhans, AJ Karhu, H Boddaert, S Tanweer… - Chemical …, 2023 - ACS Publications
The utility of carbazole in photo-, electro-, and medicinal applications has ensured its
widespread use also as the backbone in tridentate pincer ligands. In this review, the aim is …

Design, synthesis, and SAR study of novel 4, 5-dihydropyrazole-Thiazole derivatives with anti-inflammatory activities for the treatment of sepsis

Z Zhang, P Cao, M Fang, T Zou, J Han, Y Duan… - European Journal of …, 2021 - Elsevier
Systemic inflammatory response syndrome is a major feature of sepsis which is one of the
major causes of death worldwide. It has been reported that 3, 5-diaryl-4, 5-dihydropyrazole …

Rational Design of Dipicolylamine-Containing Carbazole Amphiphiles Combined with Zn2+ as Potent Broad-Spectrum Antibacterial Agents with a Membrane …

J Liu, H Li, H Li, S Fang, J Shi, Y Chen… - Journal of Medicinal …, 2021 - ACS Publications
Antibiotic resistance has become one of the most urgently important problems facing
healthcare providers. A novel series of dipicolylamine-containing carbazole amphiphiles …