Iron is a key metal involved in several biological processes such as DNA replication and
repair, cellular proliferation and cell cycle regulation. Excess volumes of labile iron are toxic …

Oxidative stress (OS) occurs when the production of reactive oxygen species (ROS)
overpowers the body's natural defence, causing macromolecular damage. The role of OS in …

Single-nucleotide-resolution sequencing of DNA damage is required to decipher the
complex causal link between the identity and location of DNA adducts and their biological …

The health and safety of using e-cigarette products (vaping) have been challenging to
assess and further regulate due to their complexity. Inhaled e-cigarette aerosols contain …

Purines, which are regarded as relatively stable heterocyclic systems, can be opened at
both pyrimidine and imidazole rings. Purine ring opening also serves as a tool for the …

Human exposure to known carcinogen 1, 3-butadiene (BD) is common due to its high
concentrations in automobile exhaust, cigarette smoke, and forest fires, as well as its …

Methoxychlor (MXC) is an organopesticide classified as a “Proposed Persistent Organic
Pollutant” in the Stockholm Convention, and recent studies revealed that MXC could induce …

The interpretation and significance of DNA adduct data, their causal relationship to
mutations, and their role in risk assessment have been debated for many years. An …

Nitrogen mustards (NM) are an important class of chemotherapeutic drugs used in the
treatment of malignant tumors. The accepted mechanism of action of NM is through the …

Acrylamide, a common food contaminant, is metabolically activated to glycidamide, which
reacts with DNA at the N7 position of dG, forming N7-(2-carbamoyl-2-hydroxyethyl)-dG (GA …