Abstract PROteolysis TArgeting Chimeras (PROTACs) technology is a new protein-
degradation strategy that has emerged in recent years. It uses bifunctional small molecules …

Dysregulation of mRNA translation is a frequent feature of neoplasia. Many oncogenes and
tumour suppressors affect the translation machinery, making aberrant translation a …

Ferroptosis is a type of lipid peroxidation-dependent cell death that is emerging as a
therapeutic target for cancer. However, the mechanisms of ferroptosis during the generation …

The central role of phosphoinositide 3-kinase (PI3K) activation in tumour cell biology has
prompted a sizeable effort to target PI3K and/or downstream kinases such as AKT and …

Growth factor signaling plays a pivotal role in diverse biological functions, such as cell
growth, apoptosis, senescence, and migration and its deregulation has been linked to …

Abstract G-quadruplexes (G4s) are non-classical DNA or RNA secondary structures that
have been first observed decades ago. Over the years, these four-stranded structural motifs …

An outstanding mystery in biology is why some species, such as the axolotl, can regenerate
tissues whereas mammals cannot. Here, we demonstrate that rapid activation of protein …

Thiazole, a unique heterocycle containing sulphur and nitrogen atoms, occupies an
important place in medicinal chemistry. It is an essential core scaffold present in many …

In eukaryotic cells, protein synthesis typically begins with the binding of eIF4F to the 7-
methylguanylate (m 7 G) cap found on the 5′ end of the majority of mRNAs. Surprisingly …

The mammalian target of rapamycin, mTOR, plays key roles in cell growth and proliferation,
acting at the catalytic subunit of two protein kinase complexes: mTOR complexes 1 and 2 …