Natural killer (NK) cells, the large granular lymphocytes differentiated from the common
lymphoid progenitors, were discovered in early 1970's. They are members of innate …

Multiple sclerosis (MS) is a chronic inflammatory disease characterized by central nervous
system (CNS) lesions that can lead to severe physical or cognitive disability as well as …

The prevalence of multiple sclerosis (MS) and the age of affected patients are increasing
owing to increased longevity of the general population and the availability of effective …

Differences in susceptibility to immune-mediated diseases are determined by variability in
immune responses. In three studies within the Human Functional Genomics Project, we …

Overactivation of microglia is associated with most neurodegenerative diseases. In this
study we examined whether PET-measurable innate immune cell activation predicts multiple …

Experimental autoimmune encephalomyelitis is a model for multiple sclerosis. Here we
show that induction generates successive waves of clonally expanded CD4+, CD8+ and γδ+ …

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS).
Microglia are the resident innate immune cells in the CNS; they play an important role in the …

Multiple sclerosis (MS) is a chronic inflammatory autoimmune demyelinating disease of the
central nervous system. It affects approximately 400,000 people in the United States and …

It is unsurprising that our understanding of the role of selenium in neurological function is
somewhat immature, considering its relatively recent discovery as an essential element to …

Age-related diseases are associated with increased morbidity in the past few decades and
the cost associated with the treatment of these age-related diseases exerts a substantial …