Membrane contact sites (MCS) between organelles of eukaryotic cells provide structural
integrity and promote organelle homeostasis by facilitating intracellular signaling, exchange …

Dynamic interactions between organelles are responsible for a variety of intercellular
functions, and the endoplasmic reticulum (ER)–mitochondrial axis is recognized as a …

Membrane contact sites (MCSs) link organelles to coordinate cellular functions across space
and time. Although viruses remodel organelles for their replication cycles, MCSs remain …

Mitochondria are the cytoplasmic organelles mostly known as the “electric engine” of the
cells; however, they also play pivotal roles in different biological processes, such as cell …

Tumor cells exhibit altered cholesterol content. However, cholesterol structural subcellular
distribution and implication in cancer cell invasion are poorly understood mainly due to …

Cancer cells undergo drastic metabolic adaptions to cover increased bioenergetic needs,
contributing to resistance to therapies. This includes a higher demand for cholesterol, which …

Nowadays, the nutraceutical agent sulforaphane (SFN) shows great versatility in turning on
different cellular responses. Mainly, this isothiocyanate acts as a master regulator of cellular …

Plasma membrane proteins are a special class of biomolecules present on the cellular
membrane. They provide the transport of ions, small molecules, and water in response to …

To maintain cellular homeostasis and to coordinate the proper response to a specific
stimulus, information must be integrated throughout the cell in a well-organized network, in …

In recent years, membrane contact sites (MCS), which mediate interactions between virtually
all subcellular organelles, have been extensively characterized and shown to be essential …