The calibrated application of limited-duration, cyclic, moderately intense hypoxia-
reoxygenation increases cardiac resistance to ischemia-reperfusion stress. These …

Hypoxia is one of the most frequently encountered stresses in health and disease. The
duration, frequency, and severity of hypoxic episodes are critical factors determining …

Background Obstructive sleep apnea (OSA) is characterized by intermittent hypoxia (IH). In
animal models, IH has been shown to protect the myocardium during periods of ischemia by …

Obesity is an important public health problem worldwide and is a major risk factor for a
number of chronic diseases such as type II diabetes, adverse cardiovascular events and …

The global industrialization has brought profound lifestyle changes and environmental
pollutions leading to higher risks of cardiovascular diseases. Such tremendous challenges …

Although intermittent hypoxia training (IHT) has proven effective against various clinical
disorders, its impact on mild cognitive impairment (MCI) is unknown. This pilot study …

Alzheimer's disease (AD) is a leading cause of death and disability among older adults.
Modifiable vascular risk factors for AD (VRF) include obesity, hypertension, type 2 diabetes …

The cellular response to hypoxia is regulated through enzymatic oxygen sensors, including
the prolyl hydroxylases, which control degradation of the well-known hypoxia inducible …

Intermittent hypoxia (IH) has a dual nature. On the one hand, chronic IH (CIH) is an important
pathologic feature of obstructive sleep apnea (OSA) syndrome (OSAS), and many studies …

Low oxygen delivery to organs and tissues is one of the most life-threatening situations.
Periodic hypoxic episodes may have not only damaging, but also protective effects on the …