Over the past two decades, bile acids (BAs) have become established as important
signaling molecules that enable fine-tuned inter-tissue communication from the liver, their …

Bile acids are signaling molecules that coordinately regulate metabolism and inflammation
via the nuclear farnesoid X receptor (FXR) and the Takeda G protein-coupled receptor 5 …

The host and microbiome appear to regulate bile acid pool size. The host produces a large,
conjugated hydrophilic bile acid pool, maintained through positive-feedback antagonism of …

Bile acids (BAs) are cholesterol-derived metabolites that facilitate the intestinal absorption
and transport of dietary lipids. Recently, BAs also emerged as pivotal signaling molecules …

In addition to their classical roles as detergents to aid in the process of digestion, bile acids
have been identified as important signaling molecules that function through various nuclear …

Bile acids (BAs) are a group of amphiphilic molecules consisting of a rigid steroid core
attached to a hydroxyl group with a varying number, position, and orientation, and a …

High-fat diet (HFD) leads to systemic low-grade inflammation, which has been involved in
the pathogenesis of diverse metabolic and inflammatory diseases. Colon is thought to be the …

Bile acids (BA) are amphipathic steroid acids synthesized from cholesterol in the liver. They
act as detergents to expedite the digestion and absorption of dietary lipids and lipophilic …

The gut microbiota is critical to human health, such as digesting nutrients, forming the
intestinal epithelial barrier, regulating immune function, producing vitamins and hormones …

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy‐specific liver disease. The
maternal symptoms are characterized by skin pruritus and elevated bile acids, causing …