Deuterated drugs and biomarkers in the COVID-19 pandemic

RD Jansen-van Vuuren, L Jedlovčnik, J Košmrlj… - ACS …, 2022 - ACS Publications
Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Initially identified in Wuhan …

The quest for secondary pharmaceuticals: drug repurposing/chiral-switches combination strategy

I D'Acquarica, I Agranat - ACS Pharmacology & Translational …, 2023 - ACS Publications
Drug repurposing toward new medical uses and chiral switches are elements of secondary
pharmaceuticals. The drug repurposing and chiral-switches strategies have mostly been …

Polypharmacology guided drug repositioning approach for SARS-CoV2

E Jamir, H Sarma, L Priyadarsinee, K Kiewhuo… - PLoS …, 2023 - journals.plos.org
Drug repurposing has emerged as an important strategy and it has a great potential in
identifying therapeutic applications for COVID-19. An extensive virtual screening of 4193 …

In Silico Models for Anti‐COVID‐19 Drug Discovery: A Systematic Review

OH Onyango - Advances in pharmacological and …, 2023 - Wiley Online Library
The coronavirus disease 2019 (COVID‐19) is a severe worldwide pandemic. Due to the
emergence of various SARS‐CoV‐2 variants and the presence of only one Food and Drug …

Hybrid approach to identifying druglikeness leading compounds against COVID-19 3CL protease

I Aqeel, M Bilal, A Majid, T Majid - Pharmaceuticals, 2022 - mdpi.com
SARS-CoV-2 is a positive single-strand RNA-based macromolecule that has caused the
death of more than 6.3 million people since June 2022. Moreover, by disturbing global …

[HTML][HTML] Bioinformatic approach for repurposing immunomodulatory drugs for lepromatous leprosy

GJ Espitia, NE Arenas… - The International …, 2023 - journals.lww.com
Background: The lepromatous leprosy (LL) disease is caused by Mycobacterium leprae and
Mycobacterium lepromatosis which is characterized by inadequate response to treatment, a …

International regulatory and publicly-funded initiatives to advance drug repurposing

EL Spin, AK Mantel-Teeuwisse… - Frontiers in Medicine, 2024 - frontiersin.org
Introduction Although drug repurposing holds great potential in addressing unmet needs,
successful practical implementation is challenging and has been less widespread than …

Identifying key biomarkers and therapeutic candidates for post-COVID-19 depression through integrated omics and bioinformatics approaches

Y Zhou, C Yang, J Zhou, Q Zhang, X Sui… - Translational …, 2024 - degruyter.com
Introduction Depression, the leading cause of disability worldwide, is known to be
exacerbated by severe acute respiratory syndrome coronavirus 2 infection, worsening …

Antibiotic Bacteria Interaction: Dataset and Benchmarking.

S Chatterjee, A Majumdar, E Chouzenoux - bioRxiv, 2024 - biorxiv.org
This study introduces a dataset for drug-bacteria associations (DBA) that affects humans.
Our contribution extends beyond merely curating the association matrix; we also conduct …

[PDF][PDF] Identification of the most potent bioactive natural compound as main protease inhibitor of SARS-CoV-2: Molecular docking, molecular dynamics simulations and …

S Begum - Network Biology, 2024 - iaees.org
Emergence of COVID-19 and thereafter intensive research on bioactive natural compounds
against SARS-CoV-2, identified a large number of phytochemicals (ie, plants-derived) and …