Microbicides have become a principal focus for HIV prevention strategies. The successful
design of drug delivery systems for vaginal microbicide drug candidates brings with it a …

The HIV epidemic is, by many criteria, the worst outbreak of infectious disease in history. The
rate of new infections is now∼ 5 million per year, mainly in the developing world, and is …

Objective: To determine the safety and effectiveness of BufferGel and 0.5% PRO2000
microbicide gels for the prevention of male-to-female HIV transmission. Design: Phase II/IIb …

Pre-exposure prophylaxis (PrEP) for HIV prevention has evolved significantly over the years
where clinical trials have now demonstrated the efficacy of oral PrEP, and the field is scaling …

Worldwide, nearly half of all individuals living with HIV are now women, who acquire the
virus largely by heterosexual exposure. With an HIV vaccine likely to be years away, topical …

Many chemical agents can block human immunodeficiency virus (HIV) infection in the
laboratory. Scientists are investigating which of these, used intravaginally by women, will …

There is an urgent need for new strategies to combat infectious diseases in developing
countries. Many pathogens have evolved to elude immunity and this has limited the utility of …

Objectives: To establish the highest practical dose and frequency (HPDF) of 0.3% or 1%
tenofovir vaginal gel applied once or twice daily by sexually abstinent HIV-uninfected …

Abstract Introduction: Female sex workers (FSWs) are at high-risk for HIV acquisition in
South Africa, where the advent of new HIV prevention and treatment interventions represent …

Microbicides represent a potential intervention strategy for preventing HIV transmission.
Vaginal microbicides would meet the need for a discreet method that women could use to …