Although Alzheimer's disease (AD) is the world's leading cause of dementia and the
population of patients with AD continues to grow, no new therapies have been approved in …

Behavioural and psychological symptoms of dementia (BPSD) occur in most patients with
dementia. They cause great suffering in patients and caregivers, sometimes more so than …

The International Conference on Harmonization considers older people a 'special
population', as they differ from younger adults in terms of comorbidity, polypharmacy …

Objective Behavioral and psychological symptoms are common in dementia, and they are
especially stressful for family caregivers. Nonpharmacological (or psychosocial) …

Background: The purpose of this review is to evaluate the data on the use of antipsychotics
in individuals with dementia from meta-analyses. Methods: We performed a literature search …

Context Atypical antipsychotic medications are commonly used for off-label conditions such
as agitation in dementia, anxiety, and obsessive-compulsive disorder. Objective To perform …

Importance Atypical antipsychotics offer modest effectiveness compared with placebo but
with serious safety risks, including a boxed warning for the risk of death in the treatment of …

Background Second-generation (atypical) antipsychotic drugs are widely used to treat
psychosis, aggression, and agitation in patients with Alzheimer's disease, but their benefits …

Objectives: Agitation in nursing home residents with dementia leads to increase in
psychotropic medication, decrease in quality of life, and to patient distress and caregiver …

Neuropsychiatric symptoms are common in Parkinson's disease, even at the earliest stages,
and have important consequences for quality of life and daily functioning, are associated …