The incidence and prevalence of chronic kidney disease (CKD), with diabetes and
hypertension accounting for the majority of cases, is on the rise, with up to 160 million …

The endothelin system consists of two G-protein-coupled receptors, three peptide ligands,
and two activating peptidases. Its pharmacological complexity is reflected by the diverse …

The 21-amino acid peptide endothelin-1 (ET-1) is the predominant isoform of the endothelin
peptide family, which includes ET-2, ET-3, and ET-4. It exerts various biological effects …

Summary Endothelin-1 (ET-l), a 21-residue vasoactive peptide, is produced in vascular
endothelial cells from the 38-residue inactive intermediate big endothelin-1 via a specific …

Heart failure is a major health problem worldwide. In the United States, it represents the
number one hospital discharge diagnosis among elderly persons each year. It appears most …

Since its identification as an endothelial cell-derived vasoconstrictor peptide in 1988,
endothelin-1, the predominant member of the endothelin peptide family, has received …

The concept of reversing chronic kidney disease (CKD) has been intensively researched
over the past decade. Indeed, as the prevalence of end-stage renal disease is constantly on …

The endothelins are a family of endothelium-derived peptides that possess characteristically
sustained vasoconstrictor properties. Endothelin-1 appears to be the predominant member …

The human endothelin-1 (ET-1) gene under the control of its natural promoter was
transferred into the germline of mice. The transgene was expressed predominantly in the …

Endothelin-1 (ET-1) is a 21-amino acid peptide that potently modulates renal function. ET-1
is produced by, and binds to, most renal cell types. ET-1 exerts a wide range of biologic …