Leishmania are kinetoplastid pathogens that cause leishmaniasis, a debilitating and
potentially life-threatening infection if untreated. Unusually, Leishmania regulate their gene …

Leishmaniasis is one of the major neglected tropical diseases, for which no vaccines exist.
Chemotherapy is hampered by limited efficacy coupled with development of resistance and …

Leishmaniasis is a vector-borne disease caused by a protozoa parasite from over 20
Leishmania species. The clinical manifestations and the outcome of the disease vary …

It is well established that infection with Leishmania alters the host cell's transcriptome. Since
mammalian cells have multiple mechanisms to control gene expression, different molecules …

Trypanosomatids are easy to cultivate and they are (in many cases) amenable to genetic
manipulation. Genome sequencing has become a standard tool routinely used in the study …

Protozoan parasite diseases cause significant mortality and morbidity worldwide. Factors
such as climate change, extreme poverty, migration, and a lack of life opportunities lead to …

Long non-coding RNAs (lncRNAs) emerged in the past 20 years due to massive amounts of
scientific data regarding transcriptomic analyses. They have been implicated in a plethora of …

Leishmania parasites cause cutaneous leishmaniasis (CL), a disease characterized by
disfiguring, ulcerative skin lesions. Both parasite and host gene expression following …

Telomeres from different eukaryotes, including trypanosomatids, are transcribed into TERRA
noncoding RNAs, crucial in regulating chromatin deposition and telomere length. TERRA is …

Highlights•Genomes and transcriptomes: illuminating possible phenotype/genotype
correlation.•Genome-wide studies of clinical isolates reveal diversity in the field and lab …