Tumor-related molecular mechanisms of oxaliplatin resistance
E Martinez-Balibrea, A Martínez-Cardús, A Ginés… - Molecular cancer …, 2015 - AACR
Oxaliplatin was the first platinum drug with proven activity against colorectal tumors,
becoming a standard in the management of this malignancy. It is also considered for the …
becoming a standard in the management of this malignancy. It is also considered for the …
Gut microbiota is critical for the induction of chemotherapy-induced pain
Chemotherapy-induced pain is a dose-limiting condition that affects 30% of patients
undergoing chemotherapy. We found that gut microbiota promotes the development of …
undergoing chemotherapy. We found that gut microbiota promotes the development of …
Microsatellite instability as a marker of prognosis and response to therapy: a meta-analysis of colorectal cancer survival data
C Guastadisegni, M Colafranceschi, L Ottini… - European journal of …, 2010 - Elsevier
BACKGROUND AND METHODS: We have reviewed and pooled data from published
studies to evaluate the relationship between microsatellite instability (MSI) and colorectal …
studies to evaluate the relationship between microsatellite instability (MSI) and colorectal …
[HTML][HTML] Oxaliplatin and its derivatives–An overview
PD O'Dowd, DF Sutcliffe, DM Griffith - Coordination Chemistry Reviews, 2023 - Elsevier
Oxaliplatin was the third Pt-based anticancer drug to be clinically used worldwide. It exhibits
a broad spectrum of anticancer activity and was the first to be approved for the treatment of …
a broad spectrum of anticancer activity and was the first to be approved for the treatment of …
[HTML][HTML] DNA damage tolerance: a double-edged sword guarding the genome
G Ghosal, J Chen - Translational cancer research, 2013 - ncbi.nlm.nih.gov
Preservation of genome integrity is an essential process for cell homeostasis. During the
course of life of a single cell, the genome is constantly damaged by endogenous and …
course of life of a single cell, the genome is constantly damaged by endogenous and …
Base and nucleotide excision repair facilitate resolution of platinum drugs-induced transcription blockage
J Slyskova, M Sabatella, C Ribeiro-Silva… - Nucleic acids …, 2018 - academic.oup.com
Sensitivity and resistance of cells to platinum drug chemotherapy are to a large extent
determined by activity of the DNA damage response (DDR). Combining chemotherapy with …
determined by activity of the DNA damage response (DDR). Combining chemotherapy with …
Platinum salts in patients with breast cancer: a focus on predictive factors
Breast cancer (BC) is the most frequent oncologic cause of death among women and the
improvement of its treatments is compelling. Platinum salts (eg, carboplatin, cisplatin, and …
improvement of its treatments is compelling. Platinum salts (eg, carboplatin, cisplatin, and …
A chemical and kinetic perspective on base excision repair of DNA
KM Schermerhorn, S Delaney - Accounts of chemical research, 2014 - ACS Publications
Conspectus Our cellular genome is continuously exposed to a wide spectrum of exogenous
and endogenous DNA damaging agents. These agents can lead to formation of an …
and endogenous DNA damaging agents. These agents can lead to formation of an …
Prognostic and predictive role of JWA and XRCC1 expressions in gastric cancer
S Wang, X Wu, Y Chen, J Zhang, J Ding, Y Zhou… - Clinical cancer …, 2012 - AACR
Purpose: To investigate the expression pattern and significance of DNA repair genes JWA
and X-ray repair cross complement group 1 (XRCC1) in gastric cancer. Experimental …
and X-ray repair cross complement group 1 (XRCC1) in gastric cancer. Experimental …