Oxaliplatin was the first platinum drug with proven activity against colorectal tumors,
becoming a standard in the management of this malignancy. It is also considered for the …

There are 15 different DNA polymerases encoded in mammalian genomes, which are
specialized for replication, repair or the tolerance of DNA damage. New evidence is …

Chemotherapy-induced pain is a dose-limiting condition that affects 30% of patients
undergoing chemotherapy. We found that gut microbiota promotes the development of …

BACKGROUND AND METHODS: We have reviewed and pooled data from published
studies to evaluate the relationship between microsatellite instability (MSI) and colorectal …

Oxaliplatin was the third Pt-based anticancer drug to be clinically used worldwide. It exhibits
a broad spectrum of anticancer activity and was the first to be approved for the treatment of …

Preservation of genome integrity is an essential process for cell homeostasis. During the
course of life of a single cell, the genome is constantly damaged by endogenous and …

Sensitivity and resistance of cells to platinum drug chemotherapy are to a large extent
determined by activity of the DNA damage response (DDR). Combining chemotherapy with …

Breast cancer (BC) is the most frequent oncologic cause of death among women and the
improvement of its treatments is compelling. Platinum salts (eg, carboplatin, cisplatin, and …

Conspectus Our cellular genome is continuously exposed to a wide spectrum of exogenous
and endogenous DNA damaging agents. These agents can lead to formation of an …

Purpose: To investigate the expression pattern and significance of DNA repair genes JWA
and X-ray repair cross complement group 1 (XRCC1) in gastric cancer. Experimental …