Molecular mechanisms of morphine tolerance and dependence; novel insights and future perspectives
Drug addiction is a devastating condition that poses a serious burden on the society. The
use of some drugs like morphine for their tremendous analgesic properties is also …
use of some drugs like morphine for their tremendous analgesic properties is also …
Ferulic acid ameliorates ulcerative colitis in a rat model via the inhibition of two LPS-TLR4-NF-κB and NF-κB-INOS-NO signaling pathways and thus alleviating the …
M Ghasemi-Dehnoo, H Amini-Khoei, Z Lorigooini… - …, 2023 - Springer
Introduction Ulcerative colitis is a chronic inflammation of the colon. However, the common
treatment for it is accompanied by many complications. Therefore, the present study was …
treatment for it is accompanied by many complications. Therefore, the present study was …
[HTML][HTML] Targeting the nitric oxide/cGMP signaling pathway to treat chronic pain
DY Li, SJ Gao, J Sun, LQ Zhang, JY Wu… - Neural Regeneration …, 2023 - journals.lww.com
Nitric oxide (NO)/cyclic guanosine 3′, 5′-monophosphate (cGMP) signaling has been
shown to act as a mediator involved in pain transmission and processing. In this review, we …
shown to act as a mediator involved in pain transmission and processing. In this review, we …
Possible role of NO/NMDA pathway in the autistic-like behaviors induced by maternal separation stress in mice
F Khaledi, HT Dehkordi, E Zarean, M Shahrani… - Plos one, 2023 - journals.plos.org
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder. Maternal
separation (MS) stress is an established model of early-life stress associated with autistic …
separation (MS) stress is an established model of early-life stress associated with autistic …
Slowly signaling G protein–biased CB2 cannabinoid receptor agonist LY2828360 suppresses neuropathic pain with sustained efficacy and attenuates morphine …
The CB2 cannabinoid agonist LY2828360 lacked both toxicity and efficacy in a clinical trial
for osteoarthritis. Whether LY2828360 suppresses neuropathic pain has not been reported …
for osteoarthritis. Whether LY2828360 suppresses neuropathic pain has not been reported …
Chronic stress but not acute stress decreases the seizure threshold in PTZ-induced seizure in mice: role of inflammatory response and oxidative stress
HT Dehkordi, E Bijad, E Saghaei, MS Korrani… - Naunyn-Schmiedeberg's …, 2023 - Springer
Seizure is paroxysmal abnormal electrical discharges in the cerebral cortex. Inflammatory
pathways and oxidative stress are involved in the pathophysiology of seizures. Stress can …
pathways and oxidative stress are involved in the pathophysiology of seizures. Stress can …
[HTML][HTML] Metabotropic glutamate receptor 5 signalling induced NMDA receptor subunits alterations during the development of morphine-induced antinociceptive …
M Huang, L Luo, Y Zhang, W Wang, J Dong… - Biomedicine & …, 2019 - Elsevier
Background and purpose The aim of this study was to investigate the interactions between
mGluR5 and NMDAR during the development of tolerance to the analgesic effect of chronic …
mGluR5 and NMDAR during the development of tolerance to the analgesic effect of chronic …
Ellagic acid through attenuation of neuro-inflammatory response exerted antidepressant-like effects in socially isolated mice
Recent studies have been demonstrated that neuroinflammation plays a crucial role in the
pathophysiology of depression. Therefore, anti-inflammatory medications could be regarded …
pathophysiology of depression. Therefore, anti-inflammatory medications could be regarded …
Atorvastatin attenuates paraquat poisoning-induced epithelial-mesenchymal transition via downregulating hypoxia-inducible factor-1 alpha
J Du, Y Zhu, X Meng, H Xie, J Wang, Z Zhou, R Wang - Life sciences, 2018 - Elsevier
Aim This study investigated the effects of atorvastatin (ATS) on the paraquat (PQ)-induced
epithelial-mesenchymal transition (EMT) and the potential mechanism through hypoxia …
epithelial-mesenchymal transition (EMT) and the potential mechanism through hypoxia …
Isoamericanin A improves lipopolysaccharide‐induced memory impairment in mice through suppression of the nicotinamide adenine dinucleotide phosphateoxidase …
Y Yang, R Chen, Y Che, X Yao, M Fang… - Phytotherapy …, 2023 - Wiley Online Library
Alzheimer's disease (AD) is the most frequent cause of dementia in the elderly.
Isoamericanin A (ISOA) is a natural lignan possessing great potential for AD treatment. This …
Isoamericanin A (ISOA) is a natural lignan possessing great potential for AD treatment. This …