Sex-specific neurotoxic effects of heavy metal pollutants: Epidemiological, experimental evidence and candidate mechanisms

M Gade, N Comfort, DB Re - Environmental research, 2021 - Elsevier
The heavy metals lead (Pb), mercury (Hg), and cadmium (Cd) are ubiquitous environmental
pollutants and are known to exert severe adverse impacts on the nervous system even at …

Biomarkers of environmental manganese exposure and associations with childhood neurodevelopment: a systematic review and meta-analysis

W Liu, Y Xin, Q Li, Y Shang, Z Ping, J Min… - Environmental …, 2020 - Springer
Background Although prior studies showed a correlation between environmental
manganese (Mn) exposure and neurodevelopmental disorders in children, the results have …

[HTML][HTML] A benchmark concentration analysis for manganese in drinking water and IQ deficits in children

SS Kullar, K Shao, C Surette, D Foucher… - Environment …, 2019 - Elsevier
Background Manganese is an essential nutrient, but in excess, can be a potent
neurotoxicant. We previously reported findings from two cross-sectional studies on children …

Manganese transporter Slc30a10 controls physiological manganese excretion and toxicity

CJ Mercadante, M Prajapati… - The Journal of …, 2019 - Am Soc Clin Investig
Manganese (Mn), an essential metal and nutrient, is toxic in excess. Toxicity classically
results from inhalational exposures in individuals who work in industrial settings. The first …

Genetics and epigenetics of manganese toxicity

S Lindner, R Lucchini, K Broberg - Current environmental health reports, 2022 - Springer
Abstract Purpose of Review At elevated levels, the essential element manganese (Mn) is
neurotoxic and increasing evidence indicates that environmental Mn exposure early in life …

An overview of the current progress, challenges, and prospects of human biomonitoring and exposome studies

MZ Bocato, JP Bianchi Ximenez… - Journal of Toxicology …, 2019 - Taylor & Francis
Human Biomonitoring (HB), the process for determining whether and to what extent
chemical substances penetrated our bodies, serves as a useful tool to quantify human …

Effect of exposure to endocrine disrupting chemicals in obesity and neurodevelopment: The genetic and microbiota link

V Ramírez, P González-Palacios, MA Baca… - Science of The Total …, 2022 - Elsevier
Current evidence highlights the importance of the genetic component in obesity and
neurodevelopmental disorders (attention-deficit hyperactivity disorder (ADHD), autism …

Role of excretion in manganese homeostasis and neurotoxicity: a historical perspective

KC Gurol, M Aschner, DR Smith… - American Journal of …, 2022 - journals.physiology.org
The essential metal manganese (Mn) induces incurable neurotoxicity at elevated levels that
manifests as parkinsonism in adults and fine motor and executive function deficits in …

Sex-specific differences in cognitive abilities associated with childhood cadmium and manganese exposures in school-age children: a prospective cohort study

T Zhou, J Guo, J Zhang, H Xiao, X Qi, C Wu… - Biological trace element …, 2020 - Springer
To examine sex-specific associations of neonatal and childhood exposure to eight trace
elements with cognitive abilities of school-age children. The association between exposure …

[HTML][HTML] Manganese transporter genetics and sex modify the association between environmental manganese exposure and neurobehavioral outcomes in children

K Broberg, T Taj, S Guazzetti, M Peli, G Cagna… - Environment …, 2019 - Elsevier
There is increasing evidence that environmental manganese (Mn) exposure early in life can
have negative effects on children's neurodevelopment and increase the risk of behavioral …