The scientific and clinical basis for the treatment of Parkinson disease (2009)
CW Olanow, MB Stern, K Sethi - Neurology, 2009 - AAN Enterprises
Parkinson disease (PD) is an age-related neurodegenerative disorder that affects as many
as 1–2% of persons aged 60 years and older. With the aging of the population, the …
as 1–2% of persons aged 60 years and older. With the aging of the population, the …
The concept of prodromal Parkinson's disease
P Mahlknecht, K Seppi… - Journal of Parkinson's …, 2015 - content.iospress.com
Parkinson's disease (PD) is currently clinically defined by a set of cardinal motor features
centred on the presence of bradykinesia and at least one additional motor symptom out of …
centred on the presence of bradykinesia and at least one additional motor symptom out of …
Dermal phospho-alpha-synuclein deposits confirm REM sleep behaviour disorder as prodromal Parkinson's disease
K Doppler, HM Jentschke, L Schulmeyer, D Vadasz… - Acta …, 2017 - Springer
Phosphorylated alpha-synuclein (p-alpha-syn) deposits, one of the neuropathological
hallmarks of Parkinson's disease (PD), have recently been detected in dermal nerve fibres in …
hallmarks of Parkinson's disease (PD), have recently been detected in dermal nerve fibres in …
[HTML][HTML] Levodopa and the progression of Parkinson's disease
Parkinson Study Group - New England Journal of Medicine, 2004 - Mass Medical Soc
Background Despite the known benefit of levodopa in reducing the symptoms of Parkinson's
disease, concern has been expressed that its use might hasten neurodegeneration. This …
disease, concern has been expressed that its use might hasten neurodegeneration. This …
The diagnosis of Parkinson's disease
The correct diagnosis of Parkinson's disease is important for prognostic and therapeutic
reasons and is essential for clinical research. Investigations of the diagnostic accuracy for …
reasons and is essential for clinical research. Investigations of the diagnostic accuracy for …
Neuroimaging in Parkinson disease: from research setting to clinical practice
M Politis - Nature Reviews Neurology, 2014 - nature.com
Over the past three decades, neuroimaging studies—including structural, functional and
molecular modalities—have provided invaluable insights into the mechanisms underlying …
molecular modalities—have provided invaluable insights into the mechanisms underlying …
Idiopathic hyposmia as a preclinical sign of Parkinson's disease
MM Ponsen, D Stoffers, J Booij… - Annals of Neurology …, 2004 - Wiley Online Library
Olfactory dysfunction is an early and common symptom in Parkinson's disease (PD). In an
effort to determine whether otherwise unexplained (idiopathic) olfactory dysfunction is …
effort to determine whether otherwise unexplained (idiopathic) olfactory dysfunction is …
Dopamine transporter imaging deficit predicts early transition to synucleinopathy in idiopathic rapid eye movement sleep behavior disorder
A Iranzo, J Santamaría, F Valldeoriola… - Annals of …, 2017 - Wiley Online Library
Objective To determine the usefulness of dopamine transporter (DAT) imaging to identify
idiopathic rapid eye movement sleep behavior disorder (IRBD) patients at risk for short‐term …
idiopathic rapid eye movement sleep behavior disorder (IRBD) patients at risk for short‐term …
Biology of Parkinson's disease: pathogenesis and pathophysiology of a multisystem neurodegenerative disorder
GE Alexander - Dialogues in clinical neuroscience, 2004 - Taylor & Francis
Parkinson's disease (PD) is the second most common movement disorder. The
characteristic motor impairments-bradykinesia, rigidity, and resting tremor-result from …
characteristic motor impairments-bradykinesia, rigidity, and resting tremor-result from …
Spatiotemporal changes in substantia nigra neuromelanin content in Parkinson's disease
This study aimed to investigate the spatiotemporal changes in neuromelanin-sensitive MRI
signal in the substantia nigra and their relation to clinical scores of disease severity in …
signal in the substantia nigra and their relation to clinical scores of disease severity in …