Parkinson disease (PD) is an age-related neurodegenerative disorder that affects as many
as 1–2% of persons aged 60 years and older. With the aging of the population, the …

Parkinson's disease (PD) is currently clinically defined by a set of cardinal motor features
centred on the presence of bradykinesia and at least one additional motor symptom out of …

Phosphorylated alpha-synuclein (p-alpha-syn) deposits, one of the neuropathological
hallmarks of Parkinson's disease (PD), have recently been detected in dermal nerve fibres in …

Background Despite the known benefit of levodopa in reducing the symptoms of Parkinson's
disease, concern has been expressed that its use might hasten neurodegeneration. This …

The correct diagnosis of Parkinson's disease is important for prognostic and therapeutic
reasons and is essential for clinical research. Investigations of the diagnostic accuracy for …

Over the past three decades, neuroimaging studies—including structural, functional and
molecular modalities—have provided invaluable insights into the mechanisms underlying …

Olfactory dysfunction is an early and common symptom in Parkinson's disease (PD). In an
effort to determine whether otherwise unexplained (idiopathic) olfactory dysfunction is …

Objective To determine the usefulness of dopamine transporter (DAT) imaging to identify
idiopathic rapid eye movement sleep behavior disorder (IRBD) patients at risk for short‐term …

Parkinson's disease (PD) is the second most common movement disorder. The
characteristic motor impairments-bradykinesia, rigidity, and resting tremor-result from …

This study aimed to investigate the spatiotemporal changes in neuromelanin-sensitive MRI
signal in the substantia nigra and their relation to clinical scores of disease severity in …