The gastrointestinal tract is the only internal organ to have evolved with its own independent
nervous system, known as the enteric nervous system (ENS). This Review provides an …

One of the most transformative developments in neurogastroenterology is the realization that
many functions normally attributed to enteric neurons involve interactions with enteric glial …

Development of the human intestine is not well understood. Here, we link single-cell RNA
sequencing and spatial transcriptomics to characterize intestinal morphogenesis through …

The enteric nervous system (ENS) coordinates diverse functions in the intestine but has
eluded comprehensive molecular characterization because of the rarity and diversity of …

The cellular landscape of the human intestinal tract is dynamic throughout life, developing in
utero and changing in response to functional requirements and environmental exposures …

Tissue maintenance and repair depend on the integrated activity of multiple cell types.
Whereas the contributions of epithelial,, immune, and stromal cells, in intestinal tissue …

The glial cell of the peripheral nervous system (PNS), the Schwann cell (SC), counts among
the most multifaceted cells of the body. During development, SCs secure neuronal survival …

The enteric nervous system (ENS) is crucial for essential gastrointestinal physiologic
functions such as motility, fluid secretion, and blood flow. The gut is colonized by trillions of …

Autonomous regulation of the intestine requires the combined activity of functionally distinct
neurons of the enteric nervous system (ENS). However, the variety of enteric neuron types …

Human organoid model systems lack important cell types that, in the embryo, are
incorporated into organ tissues during development. We developed an organoid assembly …