Looking beyond meningococcal B with the 4CMenB vaccine: the Neisseria effect

Y Ruiz García, WY Sohn, KL Seib, MK Taha… - npj Vaccines, 2021 - nature.com
Infections with Neisseria meningitidis and Neisseria gonorrhoeae have different clinical
manifestations, but the bacteria share up to 80–90% genome sequence identity. The …

Evolving strategies for meningococcal vaccination in Europe: overview and key determinants for current and future considerations

F Martinón-Torres, MK Taha, M Knuf… - … and Global Health, 2022 - Taylor & Francis
Invasive meningococcal disease (IMD) is a life-threatening, unpredictable condition.
Vaccines are available against 5 of the 6 meningococcal serogroups (Men) accounting for …

Product review on the IMD serogroup B vaccine Bexsero®

AE Deghmane, MK Taha - Human vaccines & immunotherapeutics, 2022 - Taylor & Francis
Bexsero® is a multicomponent vaccine composed of four major proteins of Neisseria
meningitidis: the fHbp, NHBA, NadA and PorA. This vaccine was licensed against invasive …

Outcomes of meningococcal serogroup B disease in children after implementation of routine infant 4CMenB vaccination in England: an active, prospective, national …

AA Mensah, H Campbell, SA Clark… - The Lancet Child & …, 2023 - thelancet.com
Background In 2015, the UK included 4CMenB, a multi-component, recombinant protein-
based vaccine against meningococcal serogroup B (MenB) disease, in the national infant …

4CMenB journey to the 10-year anniversary and beyond

V Abitbol, F Martinón-Torres, MK Taha… - Human Vaccines & …, 2024 - Taylor & Francis
The 4-component meningococcal serogroup B (MenB) vaccine, 4CMenB, the first broadly
protective, protein-based MenB vaccine to be licensed, is now registered in more than 50 …

Type 5 secretion system antigens as vaccines against Gram-negative bacterial infections

RM Da Costa, JL Rooke, TJ Wells, AF Cunningham… - npj Vaccines, 2024 - nature.com
Infections caused by Gram-negative bacteria are leading causes of mortality worldwide. Due
to the rise in antibiotic resistant strains, there is a desperate need for alternative strategies to …

The propositive study: Immunogenicity and safety of a four‐component recombinant protein‐based vaccine against MenB and a quadrivalent conjugate MenACWY …

C Isitt, A Bartolf, N Andrews, S Athaide… - HIV …, 2023 - Wiley Online Library
Background People living with HIV have been shown to have an increased risk of invasive
meningococcal disease. In some countries, meningococcal vaccines are now routinely …

Immunogenicity and safety of different schedules of the meningococcal ABCWY vaccine, with assessment of long-term antibody persistence and booster responses …

T Vesikari, J Brzostek, A Ahonen… - Human Vaccines & …, 2021 - Taylor & Francis
The meningococcal serogroup B (MenB) protein vaccine, 4CMenB, combined with MenA,
MenC, MenW and MenY polysaccharide-protein conjugates for a pentavalent MenABCWY …

Past, present, and future policy considerations regarding meningococcal vaccination in the United States

DE Clements, T Olaiya, C Burman… - Expert Review of …, 2024 - Taylor & Francis
ABSTRACT Introduction In 2005, the United States Advisory Committee on Immunization
Practices (ACIP) recommended routine vaccination against invasive meningococcal disease …

[HTML][HTML] Temporal variations in the serogroup distribution of invasive meningococcal disease in Quebec, Canada, due to emerging unique clade of serogroup Y strain …

RSW Tsang, G Deceuninck, C Meilleur, J Zhou… - Journal of Infection, 2024 - Elsevier
Objective To identify recent trends in invasive meningococcal diseases (IMD) in Quebec,
Canada, with a focus on MenY cases and MenY strains. Methods IMD cases and MenY …