[HTML][HTML] ROS/oxidative stress signaling in osteoarthritis

P Lepetsos, AG Papavassiliou - … et Biophysica Acta (BBA)-Molecular Basis …, 2016 - Elsevier
Osteoarthritis is the most common joint disorder with increasing prevalence due to aging of
the population. Its multi-factorial etiology includes oxidative stress and the overproduction of …

Redox and NF-κB signaling in osteoarthritis

P Lepetsos, KA Papavassiliou… - Free Radical Biology and …, 2019 - Elsevier
Human cells have to deal with the constant production of reactive oxygen species (ROS).
Although ROS overproduction might be harmful to cell biology, there are plenty of data …

Aging and osteoarthritis

RF Loeser - Current opinion in rheumatology, 2011 - journals.lww.com
Continued progress is being made on characterizing aging-related changes in cartilage.
Additional studies are needed that focus on the tissues outside of the articular cartilage that …

An injectable extracellular matrix derived hydrogel for meniscus repair and regeneration

J Wu, Q Ding, A Dutta, Y Wang, Y Huang, H Weng… - Acta biomaterialia, 2015 - Elsevier
Tissue-derived extracellular matrix (ECM) biomaterials to regenerate the meniscus have
gained increasing attention in treating meniscus injuries and diseases, particularly for aged …

The age‐related changes in cartilage and osteoarthritis

YP Li, XC Wei, JM Zhou, L Wei - BioMed research international, 2013 - Wiley Online Library
Osteoarthritis (OA) is closely associated with aging, but its underlying mechanism is unclear.
Recent publications were reviewed to elucidate the connection between aging and OA. With …

Single-cell RNA-seq reveals transcriptomic heterogeneity and post-traumatic osteoarthritis-associated early molecular changes in mouse articular chondrocytes

A Sebastian, JL McCool, NR Hum, DK Murugesh… - Cells, 2021 - mdpi.com
Articular cartilage is a connective tissue lining the surfaces of synovial joints. When the
cartilage severely wears down, it leads to osteoarthritis (OA), a debilitating disease that …

FoxO transcription factors support oxidative stress resistance in human chondrocytes

Y Akasaki, O Alvarez‐Garcia, M Saito… - Arthritis & …, 2014 - Wiley Online Library
Objective A major signaling pathway that regulates cellular aging is the insulin/insulin‐like
growth factor 1 (IGF‐1)/phosphatidylinositol 3‐kinase (PI3K)/Akt/FoxO transcription factor …

Nanosilicate‐reinforced silk fibroin hydrogel for endogenous regeneration of both cartilage and subchondral bone

R Sheng, J Chen, H Wang, Y Luo, J Liu… - Advanced …, 2022 - Wiley Online Library
Osteochondral defects are characterized by injuries to both cartilage and subchondral bone,
which is a result of trauma, inflammation, or inappropriate loading. Due to the unique …

Efficiently directing differentiation and homing of mesenchymal stem cells to boost cartilage repair in osteoarthritis via a nanoparticle and peptide dual-engineering …

C Wu, Z Huang, J Chen, N Li, Y Cai, J Chen, G Ruan… - Biomaterials, 2025 - Elsevier
Mesenchymal stem cells (MSCs) are expected to be useful therapeutics in osteoarthritis
(OA), the most common joint disorder characterized by cartilage degradation. However …

Oxidative stress in osteoarthritis and antioxidant effect of polysaccharide from angelica sinensis

C Zhuang, Y Wang, Y Zhang, N Xu - International journal of biological …, 2018 - Elsevier
This study aimed to investigate the oxidative stress in human osteoarthritis (OA)
chondrocytes and the antioxidant effect of angelica sinensis polysaccharide (ASP) on it …