Diabetic fibrosis

I Tuleta, NG Frangogiannis - … et Biophysica Acta (BBA)-Molecular Basis of …, 2021 - Elsevier
Diabetes-associated morbidity and mortality is predominantly due to complications of the
disease that may cause debilitating conditions, such as heart and renal failure, hepatic …

The immunometabolic roles of various fatty acids in macrophages and lymphocytes

JC Rosa Neto, PC Calder, R Curi… - International Journal of …, 2021 - mdpi.com
Macrophages and lymphocytes demonstrate metabolic plasticity, which is dependent partly
on their state of activation and partly on the availability of various energy yielding and …

Leukocyte counts and T-cell frequencies differ between novel subgroups of diabetes and are associated with metabolic parameters and biomarkers of inflammation

JM Ratter-Rieck, H Maalmi, S Trenkamp, OP Zaharia… - Diabetes, 2021 - Am Diabetes Assoc
Frequencies of circulating immune cells are altered in those with type 1 and type 2 diabetes
compared with healthy individuals and are associated with insulin sensitivity, glycemic …

Peripheral immune cells in NAFLD patients: a spyhole to disease progression

SZ Lin, JG Fan - EBioMedicine, 2022 - thelancet.com
Nonalcoholic fatty liver disease (NAFLD) is a worldwide leading cause of chronic liver
disease, but we still lack ideal non-invasive tools for diagnosis and evaluation of …

Impact of common ALDH2 inactivating mutation and alcohol consumption on Alzheimer's disease

T Seike, CH Chen, D Mochly-Rosen - Frontiers in Aging Neuroscience, 2023 - frontiersin.org
Aldehyde dehydrogenase 2 (ALDH2) is an enzyme found in the mitochondrial matrix that
plays a central role in alcohol and aldehyde metabolism. A common ALDH2 polymorphism …

Targeting T cell subtypes for NAFLD and NAFLD-related HCC treatment: an opinion

C Zhang, M Yang - Frontiers in Medicine, 2021 - frontiersin.org
The increasing prevalence of non-alcoholic fatty liver disease (NAFLD), as well as its
advanced stage non-alcoholic steatohepatitis (NASH) with the progression of liver …

Controversies and opportunities in the use of inflammatory markers for diagnosis or risk prediction in fatty liver disease

J Lambrecht, F Tacke - Frontiers in Immunology, 2021 - frontiersin.org
In the Western society, non-alcoholic fatty liver disease (NAFLD), characterized by the
excessive accumulation of fat in the liver, represents the most common cause of chronic liver …

The benefit of immunotherapy in patients with hepatocellular carcinoma: a systematic review and meta-analysis

DC Guven, E Erul, TK Sahin, O Dizdar, S Yalcin… - Future …, 2022 - Taylor & Francis
Background: A systemic review of the survival benefit of immune checkpoint inhibitors (ICIs)
in phase III hepatocellular carcinoma (HCC) trials was conducted. Methods: Meta-analyses …

Crucial role of T cells in NAFLD-related disease: A review and prospect

T Mao, R Yang, Y Luo, K He - Frontiers in Endocrinology, 2022 - frontiersin.org
Nonalcoholic fatty liver disease (NAFLD) includes a series of hepatic manifestations, starting
with liver steatosis and potentially evolving towards nonalcoholic steatohepatitis (NASH) …

Noninvasive approach to indicate risk factors of nonalcoholic steatohepatitis overlapping autoimmune hepatitis based on peripheral lymphocyte pattern

A Kado, T Tsutsumi, H Yotsuyanagi, K Ikeuchi… - Journal of …, 2023 - Springer
Background Nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH)
clinically includes autoimmunity as indicated by antinuclear antibody (ANA) positivity and …