Ovarian damage from chemotherapy and current approaches to its protection
N Spears, F Lopes, A Stefansdottir… - Human reproduction …, 2019 - academic.oup.com
Background Anti-cancer therapy is often a cause of premature ovarian insufficiency and
infertility since the ovarian follicle reserve is extremely sensitive to the effects of …
infertility since the ovarian follicle reserve is extremely sensitive to the effects of …
BRCA-related ATM-mediated DNA double-strand break repair and ovarian aging
BACKGROUND Oocyte aging has significant clinical consequences, and yet no treatment
exists to address the age-related decline in oocyte quality. The lack of progress in the …
exists to address the age-related decline in oocyte quality. The lack of progress in the …
[HTML][HTML] Fundc1-dependent mitophagy is obligatory to ischemic preconditioning-conferred renoprotection in ischemic AKI via suppression of Drp1-mediated …
Abstract FUN14 domain-containing protein 1 (Fundc1)-dependent mitophagy, mainly
activated by ischemic/hypoxic preconditioning, benefits acute myocardial reperfusion injury …
activated by ischemic/hypoxic preconditioning, benefits acute myocardial reperfusion injury …
SERCA overexpression improves mitochondrial quality control and attenuates cardiac microvascular ischemia-reperfusion injury
Despite significant advances in the treatment of myocardial ischemia-reperfusion (I/R) injury,
coronary circulation is a so far neglected target of cardioprotection. In this study, we …
coronary circulation is a so far neglected target of cardioprotection. In this study, we …
Melatonin attenuates ER stress and mitochondrial damage in septic cardiomyopathy: a new mechanism involving BAP31 upregulation and MAPK‐ERK pathway
J Zhang, L Wang, W Xie, S Hu, H Zhou… - Journal of cellular …, 2020 - Wiley Online Library
Septic cardiomyopathy is associated with mitochondrial damage and endoplasmic reticulum
(ER) dysfunction. However, the upstream mediator of mitochondrial injury and ER stress has …
(ER) dysfunction. However, the upstream mediator of mitochondrial injury and ER stress has …
Inhibitors of apoptosis protect the ovarian reserve from cyclophosphamide
Y Luan, ME Edmonds, TK Woodruff… - Journal of …, 2019 - joe.bioscientifica.com
Cancer therapy can cause off-target effects including ovarian damage, which may result in
primary ovarian insufficiency in girls and premenopausal women. Loss of ovarian follicles …
primary ovarian insufficiency in girls and premenopausal women. Loss of ovarian follicles …
Understanding p53 tumour suppressor network
The mutation of TP53 gene affects half of all human cancers, resulting in impairment of the
regulation of several cellular functions, including cell cycle progression and cell death in …
regulation of several cellular functions, including cell cycle progression and cell death in …
TAp63 determines the fate of oocytes against DNA damage
Cyclophosphamide and doxorubicin lead to premature ovarian insufficiency as an off-target
effect. However, their oocyte death pathway has been debated. Here, we clarified the …
effect. However, their oocyte death pathway has been debated. Here, we clarified the …
Fuzzy interactions between the auto-phosphorylated C-terminus and the kinase domain of CK1δ inhibits activation of TAp63α
The p53 family member TAp63α plays an important role in maintaining the genetic integrity
in oocytes. DNA damage, in particular DNA double strand breaks, lead to the transformation …
in oocytes. DNA damage, in particular DNA double strand breaks, lead to the transformation …
Regulation of meiotic prophase one in mammalian oocytes
X Wang, ME Pepling - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
In female mammals, meiotic prophase one begins during fetal development. Oocytes
transition through the prophase one substages consisting of leptotene, zygotene, and …
transition through the prophase one substages consisting of leptotene, zygotene, and …