The circadian rhythm is a nearly 24‐h oscillation found in various physiological processes in
the human brain and body that is regulated by environmental and genetic factors. It is …

The complement system is increasingly recognized as a key player in the synapse loss and
cognitive impairments observed in Alzheimer's disease (AD). In particular, the process of …

Human genetics implicate defective myeloid responses in the development of late-onset
Alzheimer disease. A decline in peripheral and brain myeloid metabolism, triggering …

It has been more than a century since Pío del Río‐Hortega first characterized microglia in
histological stains of brain tissue. Since then, significant advances have been made in …

The circadian system is an evolutionarily adaptive system that synchronizes biological and
physiological activities within the body to the 24 h oscillations on Earth. At the molecular …

Mammalian physiology and cellular function are subject to significant oscillations over the
course of every 24-hour day. It is likely that these daily rhythms will affect function as well as …

Circadian rhythms are involved in the regulation of many aspects of the body, including cell
function, physical activity and disease. Circadian disturbance often predates the typical …

Background Repeated neonatal sevoflurane exposures led to neurocognitive disorders in
young mice. We aimed to assess the role of microglia and complement C1q in sevoflurane …

The circadian rhythm affects multiple physiological processes, and disruption of the
circadian system can be involved in a range of disease-related pathways. The genetic …

Microglia, a vital homeostasis-keeper of the central nervous system, perform critical
functions such as synaptic pruning, clearance of cellular debris, and participation in …