Radiation therapy induces DNA damage and inflammation leading to fibrosis. Fibrosis can
occur 4 to 12 months after radiation therapy. This process worsens with time and years …

Stringent transcriptional regulation is crucial for normal cellular biology and organismal
development. Perturbations in the proper regulation of transcription factors can result in …

Exosomes from cancer cells or immune cells, carrying bio-macromolecules or long non-
coding RNAs (lncRNAs), participate in tumor pathogenesis and progression by modulating …

The microRNA-26 family, including miR-26a, miR-26b, miR-1297 and miR-4465, is a group
of broadly conserved small RNAs with identical sequences at the seed region. The …

An increasing number of transcription factors have been shown to elicit oncogenic and
tumor suppressor activities, depending on the tissue and cell context. Activating transcription …

MicroRNAs (miRNAs) are differentially expressed and play crucial roles in cancer
development and progression. Elevated glycolysis provides survival advantage and …

Dysregulation of c-Myc is one of the most common abnormalities in human malignancies,
including esophageal cancer, one of the world's most lethal cancers. MicroRNA-26 family …

Radiotherapy is a major cancer treatment option but dose-limiting side effects such as late-
onset fibrosis in the irradiated tissue severely impair quality of life in cancer survivors. Efforts …

In contrast to the continuous increase in survival rates for many cancer entities, colorectal
cancer (CRC) and pancreatic cancer are predicted to be ranked among the top 3 cancer …

Background Epigenetics refers to the reversible functional modifications of the genome that
do not correlate to changes in the DNA sequence. The aim of this study is to understand …