This analytical review summarizes literature data and our own research on HSP70-
dependent mechanisms of neuroprotection and discusses potential pharmacological agents …

Over the past 10 years, the crisis of sepsis has remained a great challenge. According to
data from 2016, the sepsis-related mortality rate remains high. In addition, sepsis consumes …

Aim The aim of this study was to evaluate oxidative stress from glutathione depletion in
critically ill patients with a septic shock through the abnormal presence of pyroglutamic acid …

Micronutrients are indispensable for adequate metabolism, such as biochemical function
and cell production. The production of blood cells is named haematopoiesis and this …

Significance: Endothelial barrier damage, which is in part caused by excess production of
reactive oxygen, halogen and nitrogen species (ROHNS), especially peroxynitrite (ONOO−) …

Background Serum selenium levels are lower in critically ill patients as compared with
healthy controls. However, there is no data about the difference in serum selenium levels …

The objective of our study was to evaluate the association between peptidylarginine
deiminase 4 (PAD 4) concentration and its polymorphisms with mortality in patients with …

Introduction: The efficacy of selenium administration to treat severe sepsis or septic shock
remains controversial. We con-duct a systematic review and meta-analysis to explore the …

Background Oxidative stress is a key feature of sepsis and could be a common
pathophysiological pathway between septic shock and acute kidney injury (AKI) Our …

The objective of the present study was to evaluate protein carbonyl concentration as a
predictor of AKI development in patients with septic shock and of renal replacement therapy …