NMR spectroscopy is currently extensively used in binding assays for hit identification, but its
use in dissociation constant determination is more limited when compared to other …

The knowledge of structure and dynamics is crucial to explain the function of RNAs. While
nuclear magnetic resonance (NMR) is well suited to probe these for complex biomolecules …

Carbohydrates are biologically ubiquitous and are essential to the existence of all known
living organisms. Although they are better known for their role as energy sources …

Nuclear magnetic resonance (NMR) spectroscopy has contributed to structure-based drug
development (SBDD) in a unique way compared to the other biophysical methods. The …

Accurately calculating rate constants of macroscopic chemical processes from molecular
dynamics simulations is a long-sought but elusive goal. The problem is particularly relevant …

NMR provides both structural and dynamic information, which is key to connecting
intermediates and to understanding reaction pathways. However, fast exchanging catalytic …

Nuclear magnetic resonance (NMR) spectroscopy is one of the leading biophysical methods
used in the search for and design of physiologically active compounds considered as …

The unique strength of solution-state nuclear magnetic resonance (NMR) is to contribute not
only to determine high-resolution structures of macromolecules but also to provide …

Understanding biological processes requires knowledge about the structure as well as
dynamics of the involved molecules. Proteins are complex structures, which experience time …

Nuclear magnetic resonance (NMR) spectroscopy is one of the leading biophysical methods
used in the search for and design of physiologically active compounds considered as …