While only a small part of the human genome encodes for proteins, biological functions for
the so-called junk genome are increasingly being recognized through high-throughput …

Malignant tumors aberrantly overexpress various embryonic genes and proto-oncogenes,
including a variety of cancer-testis antigens (CTAs). CTAs belong to a class of testis-derived …

Colorectal neoplasia differentially expressed (CRNDE) is the most upregulated long
noncoding RNA (lncRNA) in glioma. Herein, the function and potential molecular …

Abstract Piwi-interacting RNAs (piRNAs), whose role in germline maintenance has been
established, are now also being classified as post-transcriptional regulators of gene …

Background: PIWI proteins belong to the Argonaute family. The human PIWI subfamily
genes encode four PIWI (also known as PIWI-like) proteins: PIWIL1, PIWIL2, PIWIL3, and …

Aims Piwi-like RNA-mediated gene silencing 4 (PIWIL4) or HIWI2, are seen deregulated in
human cancers and possibly play critical roles in tumorigenesis. It is unknown what role …

Piwi-interacting RNAs (piRNAs) are a newly discovered class of small non-coding RNAs
involved in silencing of transposable elements and in sequence-specific chromatin …

Small noncoding RNAs play an important role in various disease states, including cancer.
PIWI proteins, a subfamily of Argonaute proteins, and PIWI-interacting RNAs (piRNAs) were …

PIWI proteins are well known for their roles in the animal germline. They are essential for
germline development and maintenance, and together with their binding partners, the …

Recently, several studies have demonstrated that cancer cell‑derived exosomes can
facilitate tumor development and metastasis formation. However, the detailed function of …