[HTML][HTML] A narrative review of cancer-related fatigue (CRF) and its possible pathogenesis

S Yang, S Chu, Y Gao, Q Ai, Y Liu, X Li, N Chen - Cells, 2019 - mdpi.com
Many cancer patients suffer from severe fatigue when treated with chemotherapy or
radiotherapy; however, the etiology and pathogenesis of this kind of fatigue remains …

Association between pathological and MRI findings in multiple sclerosis

M Filippi, W Brück, D Chard, F Fazekas… - The Lancet …, 2019 - thelancet.com
Pathological evaluation is the gold standard for identifying processes related to multiple
sclerosis that explain disease manifestations, and for guiding the development of new …

Clinically isolated syndromes

DH Miller, DT Chard, O Ciccarelli - The Lancet Neurology, 2012 - thelancet.com
Clinically isolated syndrome (CIS) is a term that describes a first clinical episode with
features suggestive of multiple sclerosis (MS). It usually occurs in young adults and affects …

Neurodegeneration in multiple sclerosis and neuromyelitis optica

I Kawachi, H Lassmann - Journal of Neurology, Neurosurgery & …, 2017 - jnnp.bmj.com
Multiple sclerosis (MS) and neuromyelitis optica (NMO) are autoimmune demyelinating
diseases of the central nervous system (CNS), having distinct immunological and …

Thalamic atrophy in multiple sclerosis: a magnetic resonance imaging marker of neurodegeneration throughout disease

CJ Azevedo, SY Cen, S Khadka, S Liu… - Annals of …, 2018 - Wiley Online Library
Objective Thalamic volume is a candidate magnetic resonance imaging (MRI)‐based
marker associated with neurodegeneration to hasten development of neuroprotective …

[HTML][HTML] Outcome measures in clinical trials for multiple sclerosis

CEP van Munster, BMJ Uitdehaag - CNS drugs, 2017 - Springer
Due to the heterogeneous nature of the disease, it is a challenge to capture disease activity
of multiple sclerosis (MS) in a reliable and valid way. Therefore, it can be difficult to assess …

The thalamus and multiple sclerosis: modern views on pathologic, imaging, and clinical aspects

A Minagar, MH Barnett, RHB Benedict, D Pelletier… - Neurology, 2013 - AAN Enterprises
The paired thalamic nuclei are gray matter (GM) structures on both sides of the third ventricle
that play major roles in cortical activation, relaying sensory information to the higher cortical …

Measurement and clinical effect of grey matter pathology in multiple sclerosis

JJG Geurts, M Calabrese, E Fisher… - The Lancet …, 2012 - thelancet.com
During the past 10 years, the intense involvement of the grey matter of the CNS in the
pathology of multiple sclerosis has become evident. On gross inspection, demyelination in …

Mind the gap: from neurons to networks to outcomes in multiple sclerosis

DT Chard, AAS Alahmadi, B Audoin… - Nature Reviews …, 2021 - nature.com
MRI studies have provided valuable insights into the structure and function of neural
networks, particularly in health and in classical neurodegenerative conditions such as …

Spinal cord atrophy predicts progressive disease in relapsing multiple sclerosis

A Bischof, N Papinutto, A Keshavan… - Annals of …, 2022 - Wiley Online Library
Objective A major challenge in multiple sclerosis (MS) research is the understanding of
silent progression and Progressive MS. Using a novel method to accurately capture upper …