Male breast cancer is a rare malignancy that accounts for less than 1% of all cancers in men
and less than 1% of all breast cancers. But the incidence is rising and in some patient …

Occurrence of male breast cancer, a rare disease, peaks at age 71 years. Familial cases
usually have BRCA2 rather than BRCA1 mutations. Occupational risks include high …

Cancer genetics is increasingly becoming integrated into the practice of modern medical
oncology. The ability to distinguish a growing proportion of the 5% to 10% of all cancers that …

BACKGROUND: Mutations in the BRCA1 and BRCA2 genes are found in most families with
cases of both breast and ovarian cancer or with many cases of early-onset breast cancer …

Multiple genetic loci confer susceptibility to breast and ovarian cancers. We have previously
developed a model (BOADICEA) under which susceptibility to breast cancer is explained by …

Germline mutations in the BRCA1 or BRCA2 tumour-suppressor genes are strong predictors
of breast and/or ovarian cancer development. The contribution of these mutations to breast …

Estimates of the contribution of BRCA1 and BRCA2 to breast cancer incidence in outbred
populations have been based on studies that are either small or have selected for cases …

Major risks conferred by BRCA1 and BRCA2 in women are for cancers of the breast, ovary,
fallopian tube, and peritoneum. Male carriers of mutations in BRCA1 or BRCA2 are also …

Abstract Learning Objectives After completing this course, the reader will be able to:
Differentiate between the actions of oncogenes and tumor suppressor genes in the …

Breast cancer in men is a rare disease, accounting for∼ 1% of all breast cancer cases.
Although the epidemiologic literature regarding female breast cancer is extensive, relatively …