HIV infection can be effectively treated by lifelong administration of combination antiretroviral
therapy, but an effective vaccine will likely be required to end the HIV epidemic. Although the …

The outcome after infection with the human immunodeficiency virus type 1 (HIV-1) is a
complex phenotype determined by interactions among the pathogen, the human host and …

Human T cells have a diverse T‐cell receptor (TCR) repertoire that endows them with the
ability to identify and defend against a broad spectrum of antigens. The universe of possible …

ABSTRACT HIV-1 elite controllers (EC) maintain undetectable viral loads (VL) in the
absence of antiretroviral treatment. However, these subjects have heterogeneous clinical …

Background Understanding the mechanisms underlying viral control is highly relevant to
vaccine studies and elite control (EC) of HIV infection. Although numerous definitions of EC …

Background: The proportion of HIV controllers developing virologic, immunological or
clinical progression and the baseline predictors of these outcomes have not been assessed …

Restriction of HIV-1 replication in elite controllers (ECs) is frequently attributed to T cell–
mediated immune responses, while the specific contribution of innate immune cells is less …

HIV/AIDS is still a global threat despite the notable efforts made by the scientific and health
communities to understand viral infection, to design new drugs or to improve existing ones …

The CD8+ T cell noncytotoxic antiviral response (CNAR) was discovered during studies of
asymptomatic HIV-infected subjects more than 30 years ago. In contrast to CD8+ T cell …

The exceptional group of ECs has been of great help, and will continue to provide
invaluable insight with regard to reach a potential functional cure of HIV. However, there is …