Targeted protein degradation (TPD) provides unprecedented opportunities for drug
discovery. While the proteolysis-targeting chimera (PROTAC) technology has already …

Degrading pathogenic proteins by degrader technologies such as PROTACs (proteolysis-
targeting chimeras) provides promising therapeutic strategies, but selective degradation of …

As the burden of type 2 diabetes mellitus (T2DM) grows in the 21st century, the need to
understand glucose metabolism heightens. Increased gluconeogenesis is a major …

Background It has been proposed that the γ-aminobutyric acid (GABA) plays a key role in
the regulation of food intake and body weight by controlling the excitability, plasticity and the …

Obesity is one of the major metabolic syndrome risk factors upon which altered metabolic
pathways follow. This study aimed to discern altered metabolic pathways associated with …

We compared anxiety, neuromotor, and cognitive functions in mutant rats with different
allelic variants of dopamine transporter DAT knockout receiving balanced or excess in fat …

Objective Ammonia detoxification is essential for physiological well-being, and the urea
cycle in liver plays a predominant role in ammonia disposal. Nobiletin (NOB), a natural …

Gluconeogenesis overstimulation due to hepatic insulin resistance is the best-known
mechanism behind elevated glycemia in obese subjects with hepatic steatosis. This …

Obesity is one of the independent risk factors for several health problems, leading to
metabolic perturbations and for which analytical approaches ie.,“metabolomics” is needed to …

Hyperlipidic diets limit glucose oxidation and favor amino acid preservation, hampering the
elimination of excess dietary nitrogen and the catabolic utilization of amino acids. We …