Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …

Alzheimer's disease (AD) is an age-related disease pathologically defined by the deposition
of amyloid plaques and neurofibrillary tangles in the brain parenchyma. Single-cell profiling …

COVID survivors frequently experience lingering neurological symptoms that resemble
cancer-therapy-related cognitive impairment, a syndrome for which white matter microglial …

Iron dysregulation has been implicated in multiple neurodegenerative diseases, including
Parkinson's disease (PD). Iron-loaded microglia are frequently found in affected brain …

Microglia, the macrophages of the brain parenchyma, are key players in neurodegenerative
diseases such as Alzheimer's disease. These cells adopt distinct transcriptional subtypes …

As the resident immune cells in the central nervous system (CNS), microglia orchestrate
immune responses and dynamically sculpt neural circuits in the CNS. Microglial dysfunction …

Major depressive disorder represents a serious public health challenge worldwide;
however, the underlying cellular and molecular mechanisms are mostly unknown. Here, we …

The function of the mammalian brain relies upon the specification and spatial positioning of
diversely specialized cell types. Yet, the molecular identities of the cell types and their …

Melanoma brain metastasis (MBM) frequently occurs in patients with advanced melanoma;
yet, our understanding of the underlying salient biology is rudimentary. Here, we performed …

Cellular perturbations underlying Alzheimer's disease (AD) are primarily studied in human
postmortem samples and model organisms. Here, we generated a single-nucleus atlas from …