Neuroimmune system as a driving force for plasticity following CNS injury

ML O'Reilly, VJ Tom - Frontiers in cellular neuroscience, 2020 - frontiersin.org
Following an injury to the central nervous system (CNS), spontaneous plasticity is observed
throughout the neuraxis and affects multiple key circuits. Much of this spontaneous plasticity …

Serotonin 1A receptor pharmacotherapy and neuroplasticity in spinal cord injury

A Bajjig, F Cayetanot, JA Taylor, L Bodineau… - Pharmaceuticals, 2022 - mdpi.com
Spinal cord injury is associated with damage in descending and ascending pathways
between brainstem/cortex and spinal neurons, leading to loss in sensory-motor functions …

Enhanced network in corticospinal tracts after infused mesenchymal stem cells in spinal cord injury

R Hirota, M Sasaki, Y Kataoka-Sasaki… - Journal of …, 2022 - liebertpub.com
Although limited spontaneous recovery occurs after spinal cord injury (SCI), current
knowledge reveals that multiple forms of axon growth in spared axons can lead to circuit …

V2a neurons restore diaphragm function in mice following spinal cord injury

VN Jensen, EE Huffman, FL Jalufka… - Proceedings of the …, 2024 - National Acad Sciences
The specific roles that different types of neurons play in recovery from injury is poorly
understood. Here, we show that increasing the excitability of ipsilaterally projecting …

[HTML][HTML] LAR inhibitory peptide promotes recovery of diaphragm function and multiple forms of respiratory neural circuit plasticity after cervical spinal cord injury

L Cheng, A Sami, B Ghosh, MW Urban… - Neurobiology of …, 2021 - Elsevier
Chondroitin sulfate proteoglycans (CSPGs), up-regulated in and around the lesion after
traumatic spinal cord injury (SCI), are key extracellular matrix inhibitory molecules that limit …

Spontaneous respiratory plasticity following unilateral high cervical spinal cord injury in behaving rats

T Bezdudnaya, KM Hormigo, V Marchenko… - Experimental …, 2018 - Elsevier
Unilateral cervical C2 hemisection (C2Hx) is a classic model of spinal cord injury (SCI) for
studying respiratory dysfunction and plasticity. However, most previous studies were …

Diaphragm and intercostal muscle activity after mid-cervical spinal cord contusion in the rat

MH Wen, KZ Lee - Journal of neurotrauma, 2018 - liebertpub.com
The present study was designed to investigate the diaphragm and intercostal muscle activity
after unilateral mid-cervical spinal cord contusion in rats. Electromyogram (EMG) activity of …

Modulation of serotonin and adenosine 2A receptors on intermittent hypoxia-induced respiratory recovery following mid-cervical contusion in the rat

MH Wen, MJ Wu, S Vinit, KZ Lee - Journal of neurotrauma, 2019 - liebertpub.com
The present study was designed to evaluate the therapeutic effectiveness and mechanism of
acute intermittent hypoxia on respiratory function at distinct injury stages following mid …

Integration of transplanted neural precursors with the injured cervical spinal cord

VM Spruance, LV Zholudeva, KM Hormigo… - Journal of …, 2018 - liebertpub.com
Cervical spinal cord injuries (SCI) result in devastating functional consequences, including
respiratory dysfunction. This is largely attributed to the disruption of phrenic pathways, which …

5-HT7 receptor inhibition transiently improves respiratory function following daily acute intermittent hypercapnic-hypoxia in rats with chronic midcervical spinal cord …

MJ Wu, S Vinit, CL Chen… - … and Neural Repair, 2020 - journals.sagepub.com
Background. Intermittent hypoxia can induce respiratory neuroplasticity to enhance
respiratory motor outputs following hypoxic treatment. This type of respiratory neuroplasticity …