Background In experimental studies, the outcome of bacterial meningitis has been related to
the severity of inflammation in the subarachnoid space. Corticosteroids reduce this …

Bacterial meningitis is the most common serious infection of the central nervous system.
Infection of the subarachnoid space leads to cerebrospinal fluid (CSF) inflammation …

Objectives The objective of these practice guidelines is to provide clinicians with
recommendations for the diagnosis and treatment of bacterial meningitis. Patients with …

Background Dexamethasone improves outcome for some patients with bacterial meningitis,
but not others. We aimed to identify which patients are most likely to benefit from …

Objective.—To evaluate the effectiveness of dexamethasone in bacterial meningitis in the
subcategories of causative organism and timing and nature of antibiotic therapy. Data …

AIM To determine whether intellectual and cognitive impairments observed seven years
following early childhood bacterial meningitis persist into adolescence. METHODS Blinded …

To evaluate the spectrum and regulation of matrix metalloproteinases (MMPs) in bacterial
meningitis (BM), concentrations of MMP-2, MMP-3, MMP-8, and MMP-9 and endogenous …

Background Steroids are used as adjuvant treatment in childhood pyogenic meningitis to
attenuate host inflammatory responses to bacterial invasion. We aimed to assess the …

Clinicians have generally avoided prescribing corticosteroids for active infection because of
their known immunosuppressive effects and concern about long-term complications. We …

Background Bacterial meningitis is an important cause of morbidity and mortality in
developing countries, but the duration of treatment is not well established. We aimed to …